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Mercury in PDB 8phl: Human Carbonic Anhydrase II Containing 4-Fluorophenylalanine

Enzymatic activity of Human Carbonic Anhydrase II Containing 4-Fluorophenylalanine

All present enzymatic activity of Human Carbonic Anhydrase II Containing 4-Fluorophenylalanine:
4.2.1.1; 4.2.1.69;

Protein crystallography data

The structure of Human Carbonic Anhydrase II Containing 4-Fluorophenylalanine, PDB code: 8phl was solved by L.B.T.Pham, A.Costantino, L.Barbieri, V.Calderone, E.Luchinat, L.Banci, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 31.50 / 1.30
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 41.82, 40.9, 70.87, 90, 104.73, 90
R / Rfree (%) 17.8 / 19.4

Other elements in 8phl:

The structure of Human Carbonic Anhydrase II Containing 4-Fluorophenylalanine also contains other interesting chemical elements:

Zinc (Zn) 1 atom
Fluorine (F) 12 atoms

Mercury Binding Sites:

The binding sites of Mercury atom in the Human Carbonic Anhydrase II Containing 4-Fluorophenylalanine (pdb code 8phl). This binding sites where shown within 5.0 Angstroms radius around Mercury atom.
In total only one binding site of Mercury was determined in the Human Carbonic Anhydrase II Containing 4-Fluorophenylalanine, PDB code: 8phl:

Mercury binding site 1 out of 1 in 8phl

Go back to Mercury Binding Sites List in 8phl
Mercury binding site 1 out of 1 in the Human Carbonic Anhydrase II Containing 4-Fluorophenylalanine


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 1 of Human Carbonic Anhydrase II Containing 4-Fluorophenylalanine within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Hg301

b:20.6
occ:0.90
HG A:MBO301 0.0 20.6 0.9
CE1 A:MBO301 2.0 19.2 1.0
SG A:CYS206 2.4 44.5 1.0
CE6 A:MBO301 2.8 19.4 1.0
HE6 A:MBO301 2.9 23.3 1.0
CE2 A:MBO301 3.0 19.1 1.0
O A:GLN137 3.0 10.5 1.0
O A:VAL135 3.1 26.1 1.0
HE2 A:MBO301 3.1 22.9 1.0
CB A:CYS206 3.3 32.6 1.0
CA A:CYS206 3.6 19.0 1.0
C A:GLN137 3.6 11.2 1.0
N A:CYS206 3.6 12.9 1.0
C A:GLU205 3.8 12.2 1.0
N A:GLN137 3.8 13.8 1.0
C A:VAL135 3.8 20.8 1.0
O A:GLU205 4.0 12.6 1.0
CB A:LEU204 4.0 13.6 1.0
N A:GLU205 4.1 9.1 1.0
CE5 A:MBO301 4.2 19.7 1.0
O A:HOH494 4.2 21.5 1.0
C A:GLN136 4.2 15.5 1.0
N A:PRO138 4.2 11.4 1.0
CE3 A:MBO301 4.3 19.9 1.0
CA A:GLN137 4.3 12.2 1.0
CA A:PRO138 4.3 11.3 1.0
C A:LEU204 4.5 9.4 1.0
CA A:GLU205 4.5 10.1 1.0
N A:GLN136 4.5 19.0 1.0
CA A:GLN136 4.5 19.7 1.0
CA A:VAL135 4.6 17.6 1.0
CE4 A:MBO301 4.7 19.3 1.0
CA A:LEU204 4.8 10.6 1.0
O A:ALA134 4.9 12.0 1.0
O A:GLN136 4.9 17.1 1.0
CG A:LEU204 5.0 15.4 1.0
HE5 A:MBO301 5.0 23.6 1.0

Reference:

A.Costantino, L.B.T.Pham, L.Barbieri, V.Calderone, G.Ben-Nissan, M.Sharon, L.Banci, E.Luchinat. Controlling the Incorporation of Fluorinated Amino Acids in Human Cells and Its Structural Impact. Protein Sci. V. 33 E4910 2024.
ISSN: ESSN 1469-896X
PubMed: 38358125
DOI: 10.1002/PRO.4910
Page generated: Sun Aug 11 09:00:31 2024

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