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Mercury in PDB 1a42: Human Carbonic Anhydrase II Complexed with Brinzolamide

Enzymatic activity of Human Carbonic Anhydrase II Complexed with Brinzolamide

All present enzymatic activity of Human Carbonic Anhydrase II Complexed with Brinzolamide:
4.2.1.1;

Protein crystallography data

The structure of Human Carbonic Anhydrase II Complexed with Brinzolamide, PDB code: 1a42 was solved by P.A.Boriack-Sjodin, D.W.Christianson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 8.00 / 2.25
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 42.700, 41.700, 73.000, 90.00, 104.60, 90.00
R / Rfree (%) n/a / n/a

Other elements in 1a42:

The structure of Human Carbonic Anhydrase II Complexed with Brinzolamide also contains other interesting chemical elements:

Zinc (Zn) 1 atom

Mercury Binding Sites:

The binding sites of Mercury atom in the Human Carbonic Anhydrase II Complexed with Brinzolamide (pdb code 1a42). This binding sites where shown within 5.0 Angstroms radius around Mercury atom.
In total only one binding site of Mercury was determined in the Human Carbonic Anhydrase II Complexed with Brinzolamide, PDB code: 1a42:

Mercury binding site 1 out of 1 in 1a42

Go back to Mercury Binding Sites List in 1a42
Mercury binding site 1 out of 1 in the Human Carbonic Anhydrase II Complexed with Brinzolamide


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 1 of Human Carbonic Anhydrase II Complexed with Brinzolamide within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Hg362

b:32.7
occ:1.00
SG A:CYS206 2.3 17.2 1.0
CB A:CYS206 3.3 7.5 1.0
O A:GLN137 3.3 14.3 1.0
O A:GLU205 3.3 5.4 1.0
CA A:CYS206 3.4 8.9 1.0
C A:GLU205 3.6 4.8 1.0
C A:GLN137 3.6 15.0 1.0
O A:HOH331 3.6 13.4 1.0
N A:GLN137 3.6 18.9 1.0
N A:CYS206 3.7 6.7 1.0
O A:VAL135 3.8 19.8 1.0
C A:GLN136 3.9 19.1 1.0
CA A:GLN137 4.1 17.0 1.0
N A:PRO138 4.2 13.0 1.0
C A:VAL135 4.2 16.9 1.0
N A:GLU205 4.3 10.0 1.0
CA A:GLN136 4.4 18.9 1.0
O A:GLN136 4.5 22.1 1.0
N A:GLN136 4.5 14.9 1.0
CA A:PRO138 4.5 11.4 1.0
CA A:GLU205 4.5 5.4 1.0
CB A:LEU204 4.6 9.1 1.0
O A:HOH365 4.7 26.2 1.0
C A:LEU204 4.8 12.6 1.0
C A:CYS206 4.9 6.2 1.0
CA A:VAL135 4.9 16.5 1.0

Reference:

T.Stams, Y.Chen, P.A.Boriack-Sjodin, J.D.Hurt, J.Liao, J.A.May, T.Dean, P.Laipis, D.N.Silverman, D.W.Christianson. Structures of Murine Carbonic Anhydrase IV and Human Carbonic Anhydrase II Complexed with Brinzolamide: Molecular Basis of Isozyme-Drug Discrimination. Protein Sci. V. 7 556 1998.
ISSN: ISSN 0961-8368
PubMed: 9541386
Page generated: Sun Dec 13 19:01:55 2020

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