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Mercury in PDB 1am6: Carbonic Anhydrase II Inhibitor: Acetohydroxamate

Enzymatic activity of Carbonic Anhydrase II Inhibitor: Acetohydroxamate

All present enzymatic activity of Carbonic Anhydrase II Inhibitor: Acetohydroxamate:
4.2.1.1;

Protein crystallography data

The structure of Carbonic Anhydrase II Inhibitor: Acetohydroxamate, PDB code: 1am6 was solved by L.R.Scolnick, A.M.Clements, D.W.Christianson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 6.00 / 2.00
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 42.700, 41.700, 73.000, 90.00, 92.00, 90.00
R / Rfree (%) 16 / 22

Other elements in 1am6:

The structure of Carbonic Anhydrase II Inhibitor: Acetohydroxamate also contains other interesting chemical elements:

Zinc (Zn) 1 atom

Mercury Binding Sites:

The binding sites of Mercury atom in the Carbonic Anhydrase II Inhibitor: Acetohydroxamate (pdb code 1am6). This binding sites where shown within 5.0 Angstroms radius around Mercury atom.
In total only one binding site of Mercury was determined in the Carbonic Anhydrase II Inhibitor: Acetohydroxamate, PDB code: 1am6:

Mercury binding site 1 out of 1 in 1am6

Go back to Mercury Binding Sites List in 1am6
Mercury binding site 1 out of 1 in the Carbonic Anhydrase II Inhibitor: Acetohydroxamate


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 1 of Carbonic Anhydrase II Inhibitor: Acetohydroxamate within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Hg483

b:26.4
occ:1.00
O A:HOH448 2.8 34.7 1.0
CB A:CYS206 2.9 20.7 1.0
O A:GLN137 3.1 9.4 1.0
O A:HOH362 3.3 29.2 1.0
O A:GLU205 3.3 9.9 1.0
C A:GLN137 3.4 14.2 1.0
CA A:CYS206 3.5 15.6 1.0
O A:VAL135 3.5 19.0 1.0
C A:GLU205 3.6 12.3 1.0
H A:GLN137 3.6 0.0 1.0
N A:GLN137 3.6 16.2 1.0
N A:CYS206 3.7 12.3 1.0
O A:HOH331 3.8 11.5 1.0
SG A:CYS206 3.8 43.4 1.0
C A:GLN136 3.9 17.6 1.0
N A:PRO138 4.0 12.5 1.0
C A:VAL135 4.0 16.6 1.0
CA A:GLN137 4.0 14.4 1.0
CA A:GLN136 4.3 17.2 1.0
O A:GLN136 4.3 18.7 1.0
O A:HOH365 4.3 20.3 1.0
CA A:PRO138 4.4 13.2 1.0
N A:GLN136 4.4 16.4 1.0
H A:GLU205 4.4 0.0 1.0
H A:CYS206 4.4 0.0 1.0
N A:GLU205 4.5 11.6 1.0
CA A:GLU205 4.6 10.7 1.0
CB A:LEU204 4.8 13.1 1.0
CA A:VAL135 4.9 16.8 1.0
C A:CYS206 4.9 12.1 1.0
C A:LEU204 5.0 12.8 1.0

Reference:

L.R.Scolnick, A.M.Clements, J.Liao, L.Crenshaw, M.Hellberg, J.May, T.R.Dean, D.W.Christianson. Novel Binding Mode of Hydroxamate Inhibitors to Human Carbonic Anhydrase II J.Am.Chem.Soc. V. 119 850 1997.
ISSN: ISSN 0002-7863
Page generated: Wed Oct 28 18:38:45 2020

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