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Mercury in PDB 1avn: Human Carbonic Anhydrase II Complexed with the Histamine Activator

Enzymatic activity of Human Carbonic Anhydrase II Complexed with the Histamine Activator

All present enzymatic activity of Human Carbonic Anhydrase II Complexed with the Histamine Activator:
4.2.1.1;

Protein crystallography data

The structure of Human Carbonic Anhydrase II Complexed with the Histamine Activator, PDB code: 1avn was solved by F.Briganti, S.Mangani, P.Orioli, A.Scozzafava, G.Vernaglione, C.T.Supuran, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 15.00 / 2.00
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 42.610, 41.690, 72.780, 90.00, 104.24, 90.00
R / Rfree (%) 15.4 / n/a

Other elements in 1avn:

The structure of Human Carbonic Anhydrase II Complexed with the Histamine Activator also contains other interesting chemical elements:

Zinc (Zn) 1 atom

Mercury Binding Sites:

The binding sites of Mercury atom in the Human Carbonic Anhydrase II Complexed with the Histamine Activator (pdb code 1avn). This binding sites where shown within 5.0 Angstroms radius around Mercury atom.
In total only one binding site of Mercury was determined in the Human Carbonic Anhydrase II Complexed with the Histamine Activator, PDB code: 1avn:

Mercury binding site 1 out of 1 in 1avn

Go back to Mercury Binding Sites List in 1avn
Mercury binding site 1 out of 1 in the Human Carbonic Anhydrase II Complexed with the Histamine Activator


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 1 of Human Carbonic Anhydrase II Complexed with the Histamine Activator within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Hg263

b:13.0
occ:1.00
 SG A:CYS206 2.2 7.4 1.0
O A:GLN137 3.1 7.2 1.0
O A:HOH420 3.1 34.5 1.0
O A:GLU205 3.4 4.7 1.0
CB A:CYS206 3.4 3.3 1.0
O A:HOH347 3.4 15.9 1.0
C A:GLN137 3.5 6.2 1.0
CA A:CYS206 3.6 2.6 1.0
C A:GLU205 3.7 5.0 1.0
O A:HOH309 3.7 41.8 1.0
N A:GLN137 3.8 9.0 1.0
N A:CYS206 3.8 3.6 1.0
N A:PRO138 4.0 7.5 1.0
O A:HOH302 4.0 17.7 1.0
O A:VAL135 4.1 10.5 1.0
CA A:GLN137 4.1 7.4 1.0
C A:GLN136 4.2 10.4 1.0
CA A:PRO138 4.2 6.4 1.0
C A:VAL135 4.4 6.7 1.0
N A:GLU205 4.5 5.1 1.0
N A:GLN136 4.6 6.0 1.0
CA A:GLU205 4.6 2.2 1.0
CA A:GLN136 4.7 12.5 1.0
O A:HOH313 4.7 22.0 1.0
O A:GLN136 4.7 12.4 1.0
C A:CYS206 5.0 5.1 1.0
CB A:LEU204 5.0 6.8 1.0
CD A:PRO138 5.0 9.8 1.0
C A:LEU204 5.0 4.3 1.0

Reference:

F.Briganti, S.Mangani, P.Orioli, A.Scozzafava, G.Vernaglione, C.T.Supuran. Carbonic Anhydrase Activators: X-Ray Crystallographic and Spectroscopic Investigations For the Interaction of Isozymes I and II with Histamine. Biochemistry V. 36 10384 1997.
ISSN: ISSN 0006-2960
PubMed: 9265618
DOI: 10.1021/BI970760V
Page generated: Sat Aug 10 23:17:34 2024

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