Mercury in PDB 1cim: The Positions of His-64 and A Bound Water in Human Carbonic Anhydrase II Upon Binding Three Structurally Related Inhibitors

Enzymatic activity of The Positions of His-64 and A Bound Water in Human Carbonic Anhydrase II Upon Binding Three Structurally Related Inhibitors

All present enzymatic activity of The Positions of His-64 and A Bound Water in Human Carbonic Anhydrase II Upon Binding Three Structurally Related Inhibitors:
4.2.1.1;

Protein crystallography data

The structure of The Positions of His-64 and A Bound Water in Human Carbonic Anhydrase II Upon Binding Three Structurally Related Inhibitors, PDB code: 1cim was solved by G.M.Smith, R.S.Alexander, D.W.Christianson, B.M.Mckeever, G.S.Ponticello, J.P.Springer, W.C.Randall, J.J.Baldwin, C.N.Habecker, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	N/A / 2.10
*Space group*	P 1 2₁ 1
*Cell size a, b, c (Å), α, β, γ (°)*	42.720, 41.930, 72.690, 90.00, 104.77, 90.00
*R / R_free (%)*	n/a / n/a

Other elements in 1cim:

The structure of The Positions of His-64 and A Bound Water in Human Carbonic Anhydrase II Upon Binding Three Structurally Related Inhibitors also contains other interesting chemical elements:

Zinc

(Zn)

1 atom

Mercury Binding Sites:

The binding sites of Mercury atom in the The Positions of His-64 and A Bound Water in Human Carbonic Anhydrase II Upon Binding Three Structurally Related Inhibitors (pdb code 1cim). This binding sites where shown within 5.0 Angstroms radius around Mercury atom.
In total only one binding site of Mercury was determined in the The Positions of His-64 and A Bound Water in Human Carbonic Anhydrase II Upon Binding Three Structurally Related Inhibitors, PDB code: 1cim:

Mercury binding site 1 out of 1 in 1cim

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Mercury Binding Sites List in 1cim

Mercury binding site 1 out of 1 in the The Positions of His-64 and A Bound Water in Human Carbonic Anhydrase II Upon Binding Three Structurally Related Inhibitors

Mono view

Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 1 of The Positions of His-64 and A Bound Water in Human Carbonic Anhydrase II Upon Binding Three Structurally Related Inhibitors within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Hg263 b:18.6 occ:1.00	HG	A:MMC263	0.0	18.6	1.0
	C	A:MMC263	2.1	16.1	1.0
	SG	A:CYS206	2.3	15.3	1.0
	O	A:GLN137	2.9	14.6	1.0
	O	A:GLU205	3.1	10.1	1.0
	CB	A:CYS206	3.1	12.4	1.0
	C	A:GLN137	3.4	14.9	1.0
	O	A:VAL135	3.5	13.2	1.0
	CA	A:CYS206	3.5	10.7	1.0
	C	A:GLU205	3.7	9.9	1.0
	N	A:GLN137	3.7	15.8	1.0
	N	A:CYS206	3.8	10.3	1.0
	C	A:GLN136	3.9	15.8	1.0
	N	A:PRO138	4.0	14.1	1.0
	CA	A:GLN137	4.0	15.5	1.0
	C	A:VAL135	4.1	13.7	1.0
	O	A:HOH365	4.2	14.3	1.0
	O	A:HOH397	4.2	12.2	1.0
	CA	A:PRO138	4.3	13.2	1.0
	O	A:GLN136	4.3	16.6	1.0
	CA	A:GLN136	4.5	15.5	1.0
	N	A:GLU205	4.5	9.8	1.0
	N	A:GLN136	4.6	13.9	1.0
	CA	A:GLU205	4.7	9.5	1.0
	CB	A:LEU204	4.8	9.5	1.0
	CA	A:VAL135	4.9	13.0	1.0
	CD	A:PRO138	5.0	13.9	1.0
	C	A:CYS206	5.0	9.3	1.0

Reference:

G.M.Smith, R.S.Alexander, D.W.Christianson, B.M.Mckeever, G.S.Ponticello, J.P.Springer, W.C.Randall, J.J.Baldwin, C.N.Habecker. Positions of His-64 and A Bound Water in Human Carbonic Anhydrase II Upon Binding Three Structurally Related Inhibitors. Protein Sci. V. 3 118 1994.
ISSN: ISSN 0961-8368
PubMed: 8142888

Page generated: Sat Aug 10 23:23:24 2024

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