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Mercury in PDB 1hed: Structural Consequences of Hydrophilic Amino-Acid Substitutions in the Hydrophobic Pocket of Human Carbonic Anhydrase II

Enzymatic activity of Structural Consequences of Hydrophilic Amino-Acid Substitutions in the Hydrophobic Pocket of Human Carbonic Anhydrase II

All present enzymatic activity of Structural Consequences of Hydrophilic Amino-Acid Substitutions in the Hydrophobic Pocket of Human Carbonic Anhydrase II:
4.2.1.1;

Protein crystallography data

The structure of Structural Consequences of Hydrophilic Amino-Acid Substitutions in the Hydrophobic Pocket of Human Carbonic Anhydrase II, PDB code: 1hed was solved by S.K.Nair, D.W.Christianson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) N/A / 2.00
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 42.700, 41.700, 73.000, 90.00, 104.60, 90.00
R / Rfree (%) n/a / n/a

Other elements in 1hed:

The structure of Structural Consequences of Hydrophilic Amino-Acid Substitutions in the Hydrophobic Pocket of Human Carbonic Anhydrase II also contains other interesting chemical elements:

Zinc (Zn) 1 atom

Mercury Binding Sites:

The binding sites of Mercury atom in the Structural Consequences of Hydrophilic Amino-Acid Substitutions in the Hydrophobic Pocket of Human Carbonic Anhydrase II (pdb code 1hed). This binding sites where shown within 5.0 Angstroms radius around Mercury atom.
In total 2 binding sites of Mercury where determined in the Structural Consequences of Hydrophilic Amino-Acid Substitutions in the Hydrophobic Pocket of Human Carbonic Anhydrase II, PDB code: 1hed:
Jump to Mercury binding site number: 1; 2;

Mercury binding site 1 out of 2 in 1hed

Go back to Mercury Binding Sites List in 1hed
Mercury binding site 1 out of 2 in the Structural Consequences of Hydrophilic Amino-Acid Substitutions in the Hydrophobic Pocket of Human Carbonic Anhydrase II


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 1 of Structural Consequences of Hydrophilic Amino-Acid Substitutions in the Hydrophobic Pocket of Human Carbonic Anhydrase II within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Hg263

b:28.0
occ:1.00
 SG A:CYS206 2.4 12.4 1.0
O A:GLN137 2.9 12.2 1.0
CB A:CYS206 3.2 9.0 1.0
C A:GLN137 3.3 12.5 1.0
O A:GLU205 3.4 6.8 1.0
N A:GLN137 3.5 14.2 1.0
CA A:CYS206 3.6 7.8 1.0
O A:VAL135 3.6 15.9 1.0
C A:GLU205 3.7 6.9 1.0
N A:CYS206 3.7 7.4 1.0
C A:GLN136 3.9 15.2 1.0
CA A:GLN137 3.9 13.3 1.0
N A:PRO138 4.0 11.8 1.0
C A:VAL135 4.1 15.4 1.0
O A:HOH300 4.1 11.5 1.0
O A:HOH314 4.3 7.4 1.0
CA A:GLN136 4.3 15.7 1.0
CA A:PRO138 4.4 11.2 1.0
N A:GLU205 4.4 6.3 1.0
N A:GLN136 4.4 15.6 1.0
O A:GLN136 4.5 15.1 1.0
CA A:GLU205 4.6 6.3 1.0
CB A:LEU204 4.7 6.9 1.0
CA A:VAL135 4.8 15.3 1.0
C A:LEU204 4.8 5.8 1.0
O A:ALA134 5.0 13.7 1.0

Mercury binding site 2 out of 2 in 1hed

Go back to Mercury Binding Sites List in 1hed
Mercury binding site 2 out of 2 in the Structural Consequences of Hydrophilic Amino-Acid Substitutions in the Hydrophobic Pocket of Human Carbonic Anhydrase II


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 2 of Structural Consequences of Hydrophilic Amino-Acid Substitutions in the Hydrophobic Pocket of Human Carbonic Anhydrase II within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Hg264

b:32.9
occ:1.00
 CB A:LEU204 3.0 6.9 1.0
O A:LEU204 3.2 5.1 1.0
SG A:CYS206 3.2 12.4 1.0
C A:LEU204 3.8 5.8 1.0
CA A:LEU204 3.9 6.5 1.0
CB A:CYS206 3.9 9.0 1.0
CD1 A:LEU141 3.9 6.0 1.0
CB A:VAL135 4.0 15.4 1.0
CB A:ALA198 4.0 3.7 1.0
CG A:LEU204 4.0 7.4 1.0
CD1 A:LEU204 4.0 7.8 1.0
CG1 A:VAL135 4.1 15.4 1.0
N A:LEU204 4.2 6.2 1.0
N A:CYS206 4.5 7.4 1.0
N A:ALA198 4.6 3.0 1.0
CA A:VAL135 4.6 15.3 1.0
CG A:LEU141 4.7 6.1 1.0
CA A:CYS206 4.7 7.8 1.0
CG2 A:VAL207 4.8 5.1 1.0
N A:GLU205 4.8 6.3 1.0
CA A:ALA198 4.9 2.9 1.0
O A:VAL135 5.0 15.9 1.0

Reference:

S.K.Nair, D.W.Christianson. Structural Consequences of Hydrophilic Amino Acid Substitutions in the Hydrophobic Pocket of Human Carbonic Anhydrase II. Biochemistry V. 32 4506 1993.
ISSN: ISSN 0006-2960
PubMed: 8485129
DOI: 10.1021/BI00068A005
Page generated: Sun Dec 13 19:03:02 2020

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