Atomistry » Mercury » PDB 1is9-1obh » 1k4t
Atomistry »
  Mercury »
    PDB 1is9-1obh »
      1k4t »

Mercury in PDB 1k4t: Human Dna Topoisomerase I (70 kDa) in Complex with the Poison Topotecan and Covalent Complex with A 22 Base Pair Dna Duplex

Enzymatic activity of Human Dna Topoisomerase I (70 kDa) in Complex with the Poison Topotecan and Covalent Complex with A 22 Base Pair Dna Duplex

All present enzymatic activity of Human Dna Topoisomerase I (70 kDa) in Complex with the Poison Topotecan and Covalent Complex with A 22 Base Pair Dna Duplex:
5.99.1.2;

Protein crystallography data

The structure of Human Dna Topoisomerase I (70 kDa) in Complex with the Poison Topotecan and Covalent Complex with A 22 Base Pair Dna Duplex, PDB code: 1k4t was solved by B.L.Staker, K.Hjerrild, M.D.Feese, C.A.Behnke, A.B.Burgin Jr., L.J.Stewart, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 19.89 / 2.10
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 57.093, 116.260, 75.217, 90.00, 94.16, 90.00
R / Rfree (%) n/a / n/a

Mercury Binding Sites:

The binding sites of Mercury atom in the Human Dna Topoisomerase I (70 kDa) in Complex with the Poison Topotecan and Covalent Complex with A 22 Base Pair Dna Duplex (pdb code 1k4t). This binding sites where shown within 5.0 Angstroms radius around Mercury atom.
In total only one binding site of Mercury was determined in the Human Dna Topoisomerase I (70 kDa) in Complex with the Poison Topotecan and Covalent Complex with A 22 Base Pair Dna Duplex, PDB code: 1k4t:

Mercury binding site 1 out of 1 in 1k4t

Go back to Mercury Binding Sites List in 1k4t
Mercury binding site 1 out of 1 in the Human Dna Topoisomerase I (70 kDa) in Complex with the Poison Topotecan and Covalent Complex with A 22 Base Pair Dna Duplex


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 1 of Human Dna Topoisomerase I (70 kDa) in Complex with the Poison Topotecan and Covalent Complex with A 22 Base Pair Dna Duplex within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Hg900

b:75.2
occ:0.36
 SG A:CYS630 2.8 44.3 1.0
CD2 A:LEU629 3.3 50.0 1.0
O A:ARG590 3.4 19.7 1.0
CB A:ALA486 3.7 42.3 1.0
CB A:ALA594 3.8 19.6 1.0
N A:ALA594 3.9 21.1 1.0
CA A:ALA594 4.0 18.8 1.0
CB A:CYS630 4.1 38.1 1.0
CA A:CYS630 4.2 38.7 1.0
CA A:ARG590 4.2 20.4 1.0
C A:ARG590 4.2 20.3 1.0
N A:CYS630 4.2 37.2 1.0
CG A:LEU629 4.5 49.4 1.0
CB A:ASN593 4.5 29.7 1.0
C A:ASN593 4.5 24.6 1.0
CB A:ARG590 4.5 25.1 1.0
C A:LEU629 4.6 39.4 1.0
CB A:LEU629 4.7 43.1 1.0
O A:VAL626 4.8 25.1 1.0
CG A:ARG590 4.9 28.3 1.0
O A:LEU629 4.9 39.2 1.0
CD1 A:LEU629 5.0 51.4 1.0

Reference:

B.L.Staker, K.Hjerrild, M.D.Feese, C.A.Behnke, A.B.Burgin Jr., L.J.Stewart. The Mechanism of Topoisomerase I Poisoning By A Camptothecin Analog Proc.Natl.Acad.Sci.Usa V. 99 15387 2002.
ISSN: ISSN 0027-8424
PubMed: 12426403
DOI: 10.1073/PNAS.242259599
Page generated: Sun Aug 11 00:19:18 2024

Last articles

Zn in 9JYW
Zn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy