Mercury in PDB 1lz0: Glycosyltransferase A

All present enzymatic activity of Glycosyltransferase A:
2.4.1.40;

The structure of Glycosyltransferase A, PDB code: 1lz0 was solved by S.I.Patenaude, N.O.L.Seto, S.N.Borisova, A.Szpacenko, S.L.Marcus, M.M.Palcic, S.V.Evans, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	20.00 / 1.80
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	52.530, 149.160, 79.370, 90.00, 90.00, 90.00
R / Rfree (%)	17.5 / 21.2

The binding sites of Mercury atom in the Glycosyltransferase A (pdb code 1lz0). This binding sites where shown within 5.0 Angstroms radius around Mercury atom.
In total 4 binding sites of Mercury where determined in the Glycosyltransferase A, PDB code: 1lz0:
Jump to Mercury binding site number: 1; 2; 3; 4;

Mercury binding site 1 out of 4 in the Glycosyltransferase A


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 1 of Glycosyltransferase A within 5.0Å range: probe atom residue distance (Å) B Occ A:Hg401 b:35.8 occ:0.50 SG A:CYS80 2.5 48.0 1.0 CB A:CYS80 2.8 40.4 1.0 O A:GLY98 2.8 25.8 1.0 CA A:CYS80 3.0 38.8 1.0 O A:HOH651 3.5 30.6 1.0 O A:HOH590 3.5 43.4 1.0 O A:HOH624 3.8 42.5 1.0 C A:GLY98 4.0 24.4 1.0 N A:CYS80 4.1 37.5 1.0 C A:CYS80 4.1 36.8 1.0 O A:CYS80 4.2 37.5 1.0 CA A:THR99 4.3 20.3 1.0 O A:HOH516 4.5 38.0 1.0 N A:THR99 4.6 21.8 1.0 C A:THR99 4.8 20.0 1.0 O A:THR99 4.8 18.5 1.0 C A:PRO79 5.0 37.0 1.0

Mercury binding site 2 out of 4 in the Glycosyltransferase A


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 2 of Glycosyltransferase A within 5.0Å range: probe atom residue distance (Å) B Occ A:Hg402 b:28.6 occ:0.50 SG A:CYS209 2.3 28.6 1.0 O A:HOH652 2.5 40.7 1.0 OG1 A:THR119 3.0 23.6 1.0 CB A:CYS209 3.2 21.9 1.0 O A:HOH503 3.8 24.0 1.0 CB A:THR119 4.0 20.8 1.0 CG2 A:THR119 4.1 22.8 1.0 CG1 A:VAL277 4.2 18.5 1.0 CA A:CYS209 4.2 20.8 1.0 CD1 A:LEU207 4.6 23.8 1.0 N A:CYS209 4.7 18.3 1.0 CZ A:PHE270 4.8 24.5 1.0 CE1 A:PHE270 4.9 24.4 1.0 CB A:LEU207 5.0 22.4 1.0

Mercury binding site 3 out of 4 in the Glycosyltransferase A


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 3 of Glycosyltransferase A within 5.0Å range: probe atom residue distance (Å) B Occ A:Hg403 b:46.0 occ:0.50 SG A:CYS284 2.6 21.2 0.5 O A:HOH591 2.7 47.4 1.0 SG A:CYS284 3.0 28.3 0.5 CB A:CYS284 3.0 26.5 0.5 CB A:CYS284 3.1 24.1 0.5 CD2 A:LEU280 3.3 25.5 1.0 CA A:LEU306 4.0 20.5 1.0 CB A:LEU306 4.1 19.3 1.0 O A:ASP302 4.1 29.1 1.0 N A:LEU306 4.1 20.4 1.0 O A:LEU280 4.4 22.7 1.0 CD1 A:LEU306 4.5 22.4 1.0 CG A:LEU280 4.5 23.0 1.0 CA A:CYS284 4.5 26.4 0.5 CA A:CYS284 4.6 24.9 0.5 C A:HIS305 4.7 21.9 1.0 HG A:HG404 4.8 41.2 0.2 CB A:HIS305 4.9 24.9 1.0 CG A:LEU306 4.9 23.5 1.0 C A:ASP302 5.0 29.0 1.0 C A:LEU280 5.0 23.1 1.0 CA A:THR281 5.0 25.8 1.0

Mercury binding site 4 out of 4 in the Glycosyltransferase A


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 4 of Glycosyltransferase A within 5.0Å range: probe atom residue distance (Å) B Occ A:Hg404 b:41.2 occ:0.25 SD A:MET288 2.7 41.3 1.0 SG A:CYS284 2.7 28.3 0.5 CB A:CYS284 3.7 26.5 0.5 N A:HIS285 3.8 27.3 1.0 C A:CYS284 3.8 26.2 0.5 CB A:CYS284 3.8 24.1 0.5 C A:CYS284 3.8 26.9 0.5 CG A:MET288 3.9 33.7 1.0 O A:CYS284 4.0 27.2 0.5 CA A:HIS285 4.0 30.1 1.0 O A:CYS284 4.1 27.7 0.5 CE A:MET288 4.1 39.5 1.0 CA A:CYS284 4.4 26.4 0.5 CA A:CYS284 4.5 24.9 0.5 CB A:ASP302 4.6 35.1 1.0 CB A:HIS285 4.7 33.6 1.0 CB A:MET288 4.7 30.5 1.0 HG A:HG403 4.8 46.0 0.5 O A:THR281 4.9 24.7 1.0

S.I.Patenaude, N.O.Seto, S.N.Borisova, A.Szpacenko, S.L.Marcus, M.M.Palcic, S.V.Evans. The Structural Basis For Specificity in Human Abo(H) Blood Group Biosynthesis. Nat.Struct.Biol. V. 9 685 2002.
ISSN: ISSN 1072-8368
PubMed: 12198488
DOI: 10.1038/NSB832