Mercury in PDB 1miu: Structure of A BRCA2-DSS1 Complex

The structure of Structure of A BRCA2-DSS1 Complex, PDB code: 1miu was solved by H.Yang, P.D.Jeffrey, J.Miller, E.Kinnucan, Y.Sun, N.H.Thoma, N.Zheng, P.L.Chen, W.H.Lee, N.P.Pavletich, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	20.00 / 3.10
Space group	C 2 2 2
Cell size a, b, c (Å), α, β, γ (°)	160.509, 228.271, 81.715, 90.00, 90.00, 90.00
R / Rfree (%)	25.6 / 31

The binding sites of Mercury atom in the Structure of A BRCA2-DSS1 Complex (pdb code 1miu). This binding sites where shown within 5.0 Angstroms radius around Mercury atom.
In total 5 binding sites of Mercury where determined in the Structure of A BRCA2-DSS1 Complex, PDB code: 1miu:
Jump to Mercury binding site number: 1; 2; 3; 4; 5;

Mercury binding site 1 out of 5 in the Structure of A BRCA2-DSS1 Complex


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 1 of Structure of A BRCA2-DSS1 Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Hg101 b:0.4 occ:0.51 O A:ALA2685 2.5 0.8 1.0 SG A:CYS2686 2.6 0.4 1.0 O A:ASP2684 3.0 0.0 1.0 CD1 A:LEU2597 3.2 77.3 1.0 O A:LEU2597 3.3 75.7 1.0 CD1 A:LEU2695 3.4 0.6 1.0 C A:ALA2685 3.7 0.0 1.0 C A:LEU2597 3.9 69.9 1.0 CB A:CYS2686 4.0 0.1 1.0 CA A:LEU2597 4.0 68.5 1.0 CB A:LEU2597 4.1 70.8 1.0 C A:ASP2684 4.2 0.9 1.0 CG A:LEU2597 4.3 75.3 1.0 N A:CYS2686 4.6 0.5 1.0 CA A:ALA2685 4.6 0.6 1.0 O A:CYS2686 4.7 0.5 1.0 CA A:CYS2686 4.8 0.5 1.0 CD A:PRO2692 4.8 0.5 1.0 N A:ALA2685 4.9 0.9 1.0 CG A:LEU2695 4.9 0.1 1.0

Mercury binding site 2 out of 5 in the Structure of A BRCA2-DSS1 Complex


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 2 of Structure of A BRCA2-DSS1 Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Hg102 b:0.1 occ:0.50 CB A:CYS3045 2.9 0.8 1.0 SG A:CYS3045 3.3 97.7 1.0 CA A:CYS3045 4.3 0.8 1.0 CD2 A:LEU2979 4.4 0.6 1.0 O A:SER2989 4.4 94.4 1.0 OG A:SER2989 4.6 0.7 1.0 O A:PHE2984 4.7 0.6 1.0 CG1 A:VAL2991 4.7 70.9 1.0 O A:GLN2985 4.8 0.9 1.0 N A:CYS3045 4.8 0.1 1.0 CA A:SER2989 5.0 0.8 1.0

Mercury binding site 3 out of 5 in the Structure of A BRCA2-DSS1 Complex


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 3 of Structure of A BRCA2-DSS1 Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Hg103 b:1.0 occ:0.50 CB A:CYS2988 3.0 0.1 1.0 O A:PRO2987 3.5 0.6 1.0 C A:PRO2987 3.5 0.5 1.0 N A:CYS2988 3.7 0.5 1.0 CB A:PRO2987 3.7 0.4 1.0 CA A:CYS2988 4.0 0.7 1.0 CA A:PRO2987 4.1 0.3 1.0 SG A:CYS2988 4.3 0.6 1.0 CD A:ARG2893 4.4 80.8 1.0 CG A:ARG2893 4.5 78.9 1.0 C A:CYS2988 4.8 0.2 1.0 OH A:TYR2747 4.8 88.3 1.0 NE A:ARG2893 4.8 92.1 1.0 CD A:GLU2990 4.8 80.8 1.0 OE2 A:GLU2990 4.9 75.7 1.0 CG A:ARG2745 4.9 70.2 1.0 NE2 A:GLN2969 4.9 0.8 1.0 CG A:GLU2990 5.0 82.3 1.0

Mercury binding site 4 out of 5 in the Structure of A BRCA2-DSS1 Complex


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 4 of Structure of A BRCA2-DSS1 Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Hg104 b:0.9 occ:0.50 SG A:CYS2567 2.7 97.2 1.0 CD1 B:LEU10 3.2 100.0 1.0 CA A:CYS2567 3.4 0.4 1.0 CB A:CYS2567 3.5 0.2 1.0 CD2 A:LEU2552 4.0 0.2 1.0 O A:ARG2566 4.1 0.1 1.0 SD A:MET2555 4.1 0.7 1.0 C A:CYS2567 4.3 0.8 1.0 O A:CYS2567 4.3 0.6 1.0 N A:CYS2567 4.4 1.0 1.0 CG B:LEU10 4.4 0.0 1.0 CD2 B:LEU10 4.5 0.6 1.0 CE A:MET2555 4.5 0.3 1.0 C A:ARG2566 4.6 0.7 1.0 CD A:ARG2572 4.8 0.4 1.0 CB B:LEU10 4.9 0.5 1.0 CD1 A:PHE2563 4.9 0.9 1.0 CG A:ARG2572 4.9 0.9 1.0

Mercury binding site 5 out of 5 in the Structure of A BRCA2-DSS1 Complex


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 5 of Structure of A BRCA2-DSS1 Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Hg105 b:0.0 occ:0.50 SG A:CYS3016 3.4 0.9 1.0 O A:GLU3015 4.2 0.2 1.0 CA A:CYS3016 4.5 0.4 1.0 CB A:CYS3016 4.5 0.4 1.0 C A:GLU3015 4.6 0.9 1.0 N A:CYS3016 4.7 0.2 1.0

H.Yang, P.D.Jeffrey, J.Miller, E.Kinnucan, Y.Sun, N.H.Thoma, N.Zheng, P.L.Chen, W.H.Lee, N.P.Pavletich. BRCA2 Function in Dna Binding and Recombination From A BRCA2-DSS1-Ssdna Structure Science V. 297 1837 2002.
ISSN: ISSN 0036-8075
PubMed: 12228710
DOI: 10.1126/SCIENCE.297.5588.1837