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Mercury in PDB 1okl: Carbonic Anhydrase II Complex with the 1OKL Inhibitor 5- Dimethylamino-Naphthalene-1-Sulfonamide

Enzymatic activity of Carbonic Anhydrase II Complex with the 1OKL Inhibitor 5- Dimethylamino-Naphthalene-1-Sulfonamide

All present enzymatic activity of Carbonic Anhydrase II Complex with the 1OKL Inhibitor 5- Dimethylamino-Naphthalene-1-Sulfonamide:
4.2.1.1;

Protein crystallography data

The structure of Carbonic Anhydrase II Complex with the 1OKL Inhibitor 5- Dimethylamino-Naphthalene-1-Sulfonamide, PDB code: 1okl was solved by S.K.Nair, D.Elbaum, D.W.Christianson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) N/A / 2.10
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 42.700, 41.700, 73.000, 90.00, 104.60, 90.00
R / Rfree (%) 18.5 / 23.3

Other elements in 1okl:

The structure of Carbonic Anhydrase II Complex with the 1OKL Inhibitor 5- Dimethylamino-Naphthalene-1-Sulfonamide also contains other interesting chemical elements:

Zinc (Zn) 1 atom

Mercury Binding Sites:

The binding sites of Mercury atom in the Carbonic Anhydrase II Complex with the 1OKL Inhibitor 5- Dimethylamino-Naphthalene-1-Sulfonamide (pdb code 1okl). This binding sites where shown within 5.0 Angstroms radius around Mercury atom.
In total only one binding site of Mercury was determined in the Carbonic Anhydrase II Complex with the 1OKL Inhibitor 5- Dimethylamino-Naphthalene-1-Sulfonamide, PDB code: 1okl:

Mercury binding site 1 out of 1 in 1okl

Go back to Mercury Binding Sites List in 1okl
Mercury binding site 1 out of 1 in the Carbonic Anhydrase II Complex with the 1OKL Inhibitor 5- Dimethylamino-Naphthalene-1-Sulfonamide


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 1 of Carbonic Anhydrase II Complex with the 1OKL Inhibitor 5- Dimethylamino-Naphthalene-1-Sulfonamide within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Hg531

b:23.4
occ:1.00
SG A:CYS205 2.1 15.2 1.0
O A:GLN136 3.1 13.7 1.0
CB A:CYS205 3.1 14.4 1.0
O A:GLU204 3.2 10.6 1.0
C A:GLN136 3.4 15.0 1.0
O A:HOH362 3.5 18.6 1.0
CA A:CYS205 3.5 11.3 1.0
N A:GLN136 3.6 17.7 1.0
C A:GLU204 3.6 11.1 1.0
O A:VAL134 3.6 19.0 1.0
N A:CYS205 3.8 9.7 1.0
O A:HOH331 3.9 21.8 1.0
C A:GLN135 3.9 18.3 1.0
N A:PRO137 4.0 13.9 1.0
CA A:GLN136 4.0 15.4 1.0
C A:VAL134 4.1 18.2 1.0
O A:HOH365 4.2 24.1 1.0
CA A:PRO137 4.3 12.6 1.0
CA A:GLN135 4.3 17.9 1.0
O A:GLN135 4.4 19.4 1.0
N A:GLN135 4.5 17.1 1.0
N A:GLU204 4.5 12.0 1.0
CA A:GLU204 4.7 11.3 1.0
CB A:LEU203 4.9 14.2 1.0
C A:CYS205 5.0 10.7 1.0

Reference:

S.K.Nair, D.Elbaum, D.W.Christianson. Unexpected Binding Mode of the Sulfonamide Fluorophore 5-Dimethylamino-1-Naphthalene Sulfonamide to Human Carbonic Anhydrase II. Implications For the Development of A Zinc Biosensor. J.Biol.Chem. V. 271 1003 1996.
ISSN: ISSN 0021-9258
PubMed: 8557623
Page generated: Wed Oct 28 18:40:17 2020

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