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Mercury in PDB 1qai: Crystal Structures of the N-Terminal Fragment From Moloney Murine Leukemia Virus Reverse Transcriptase Complexed with Nucleic Acid: Functional Implications For Template-Primer Binding to the Fingers Domain

Enzymatic activity of Crystal Structures of the N-Terminal Fragment From Moloney Murine Leukemia Virus Reverse Transcriptase Complexed with Nucleic Acid: Functional Implications For Template-Primer Binding to the Fingers Domain

All present enzymatic activity of Crystal Structures of the N-Terminal Fragment From Moloney Murine Leukemia Virus Reverse Transcriptase Complexed with Nucleic Acid: Functional Implications For Template-Primer Binding to the Fingers Domain:
2.7.7.49;

Protein crystallography data

The structure of Crystal Structures of the N-Terminal Fragment From Moloney Murine Leukemia Virus Reverse Transcriptase Complexed with Nucleic Acid: Functional Implications For Template-Primer Binding to the Fingers Domain, PDB code: 1qai was solved by S.Najmudin, M.Cote, D.Sun, S.Yohannan, S.P.Montano, J.Gu, M.M.Georgiadis, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 10.00 / 2.30
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 61.138, 38.432, 129.751, 90.00, 100.58, 90.00
R / Rfree (%) 23.3 / 29.6

Mercury Binding Sites:

The binding sites of Mercury atom in the Crystal Structures of the N-Terminal Fragment From Moloney Murine Leukemia Virus Reverse Transcriptase Complexed with Nucleic Acid: Functional Implications For Template-Primer Binding to the Fingers Domain (pdb code 1qai). This binding sites where shown within 5.0 Angstroms radius around Mercury atom.
In total 4 binding sites of Mercury where determined in the Crystal Structures of the N-Terminal Fragment From Moloney Murine Leukemia Virus Reverse Transcriptase Complexed with Nucleic Acid: Functional Implications For Template-Primer Binding to the Fingers Domain, PDB code: 1qai:
Jump to Mercury binding site number: 1; 2; 3; 4;

Mercury binding site 1 out of 4 in 1qai

Go back to Mercury Binding Sites List in 1qai
Mercury binding site 1 out of 4 in the Crystal Structures of the N-Terminal Fragment From Moloney Murine Leukemia Virus Reverse Transcriptase Complexed with Nucleic Acid: Functional Implications For Template-Primer Binding to the Fingers Domain


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 1 of Crystal Structures of the N-Terminal Fragment From Moloney Murine Leukemia Virus Reverse Transcriptase Complexed with Nucleic Acid: Functional Implications For Template-Primer Binding to the Fingers Domain within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Hg901

b:27.7
occ:0.30
 O A:HOH1007 2.0 7.3 1.0
SG A:CYS157 2.6 18.9 1.0
O A:ASP153 3.1 17.6 1.0
N A:CYS157 3.2 11.1 1.0
O A:GLY40 3.3 19.2 1.0
CA A:CYS157 3.4 12.8 1.0
N A:GLY40 3.5 21.5 1.0
C A:PHE156 3.5 12.8 1.0
CB A:CYS157 3.6 13.6 1.0
C A:GLY40 3.7 19.3 1.0
O A:PHE156 3.8 13.0 1.0
CA A:GLY40 3.9 20.2 1.0
CB A:PHE156 3.9 12.8 1.0
C A:ASP153 4.2 18.3 1.0
CA A:PHE156 4.2 11.5 1.0
CB A:ASP153 4.2 20.2 1.0
O A:HOH910 4.4 19.0 1.0
O A:LYS152 4.4 22.1 1.0
C A:MET39 4.4 23.4 1.0
CB A:MET39 4.5 24.8 1.0
N A:LEU41 4.6 17.6 1.0
O A:ALA154 4.7 7.5 1.0
N A:PHE156 4.7 12.0 1.0
CA A:MET39 4.8 23.1 1.0
CA A:ASP153 4.9 18.5 1.0
C A:CYS157 4.9 11.7 1.0
NH1 A:ARG187 5.0 22.1 1.0

Mercury binding site 2 out of 4 in 1qai

Go back to Mercury Binding Sites List in 1qai
Mercury binding site 2 out of 4 in the Crystal Structures of the N-Terminal Fragment From Moloney Murine Leukemia Virus Reverse Transcriptase Complexed with Nucleic Acid: Functional Implications For Template-Primer Binding to the Fingers Domain


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 2 of Crystal Structures of the N-Terminal Fragment From Moloney Murine Leukemia Virus Reverse Transcriptase Complexed with Nucleic Acid: Functional Implications For Template-Primer Binding to the Fingers Domain within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Hg903

b:45.1
occ:0.20
 CB A:CYS90 2.7 26.9 1.0
SG A:CYS90 2.8 33.8 1.0
O A:HOH905 3.2 9.2 1.0
O A:HOH1078 3.4 37.3 1.0
O A:HOH1016 3.5 33.7 1.0
CG A:PRO166 3.6 9.5 1.0
CA A:PRO166 3.7 8.7 1.0
CB A:PRO166 3.8 11.6 1.0
O A:HOH1011 3.9 26.7 1.0
CA A:CYS90 3.9 25.4 1.0
N A:GLN91 4.0 25.9 1.0
O A:GLN91 4.0 18.1 1.0
CG2 A:THR184 4.1 8.0 1.0
N A:PRO166 4.1 9.1 1.0
CB A:SER92 4.3 15.6 1.0
C A:CYS90 4.3 26.1 1.0
CD A:PRO166 4.4 12.3 1.0
C A:GLN91 4.4 21.3 1.0
CB A:THR184 4.7 10.0 1.0
C A:GLN165 4.8 10.7 1.0
N A:SER92 4.9 19.5 1.0
CA A:GLN91 4.9 24.7 1.0
OG A:SER92 5.0 15.6 1.0
CA A:SER92 5.0 19.2 1.0
C A:PRO166 5.0 8.1 1.0

Mercury binding site 3 out of 4 in 1qai

Go back to Mercury Binding Sites List in 1qai
Mercury binding site 3 out of 4 in the Crystal Structures of the N-Terminal Fragment From Moloney Murine Leukemia Virus Reverse Transcriptase Complexed with Nucleic Acid: Functional Implications For Template-Primer Binding to the Fingers Domain


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 3 of Crystal Structures of the N-Terminal Fragment From Moloney Murine Leukemia Virus Reverse Transcriptase Complexed with Nucleic Acid: Functional Implications For Template-Primer Binding to the Fingers Domain within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Hg902

b:52.1
occ:0.30
 O B:HOH938 2.3 26.4 1.0
O B:ASP153 2.9 34.5 1.0
SG B:CYS157 2.9 39.1 1.0
O B:GLY40 3.2 36.1 1.0
N B:CYS157 3.3 26.5 1.0
N B:GLY40 3.4 42.1 1.0
C B:PHE156 3.5 27.2 1.0
CA B:CYS157 3.6 27.1 1.0
C B:GLY40 3.6 35.7 1.0
CA B:GLY40 3.7 39.0 1.0
CB B:PHE156 3.8 29.3 1.0
O B:PHE156 3.8 27.9 1.0
CB B:CYS157 3.8 29.2 1.0
C B:ASP153 4.0 35.2 1.0
CB B:ASP153 4.1 37.9 1.0
CA B:PHE156 4.1 27.8 1.0
O B:LYS152 4.4 39.5 1.0
C B:MET39 4.5 45.1 1.0
N B:LEU41 4.6 32.1 1.0
N B:PHE156 4.6 28.3 1.0
CA B:ASP153 4.7 36.9 1.0
O B:HOH921 4.7 30.2 1.0
CB B:MET39 4.8 50.4 1.0
O B:ALA154 4.8 28.3 1.0
CA B:MET39 4.8 46.5 1.0
N B:ALA154 5.0 32.4 1.0

Mercury binding site 4 out of 4 in 1qai

Go back to Mercury Binding Sites List in 1qai
Mercury binding site 4 out of 4 in the Crystal Structures of the N-Terminal Fragment From Moloney Murine Leukemia Virus Reverse Transcriptase Complexed with Nucleic Acid: Functional Implications For Template-Primer Binding to the Fingers Domain


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 4 of Crystal Structures of the N-Terminal Fragment From Moloney Murine Leukemia Virus Reverse Transcriptase Complexed with Nucleic Acid: Functional Implications For Template-Primer Binding to the Fingers Domain within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Hg904

b:61.7
occ:0.20
 O B:HOH940 2.6 32.2 1.0
O B:HOH916 2.8 31.6 1.0
CB B:CYS90 3.0 44.0 1.0
SG B:CYS90 3.2 47.5 1.0
CG B:PRO166 3.2 27.2 1.0
CB B:PRO166 3.8 27.9 1.0
CA B:PRO166 3.9 25.8 1.0
CD B:PRO166 4.0 27.0 1.0
N B:PRO166 4.1 25.2 1.0
O B:GLN91 4.3 47.5 1.0
CA B:CYS90 4.3 44.1 1.0
CB B:SER92 4.6 43.0 1.0
N B:GLN91 4.6 46.2 1.0
CG2 B:THR184 4.6 30.3 1.0
C B:CYS90 4.7 45.0 1.0
C B:GLN165 4.8 22.9 1.0
C B:GLN91 4.8 46.5 1.0
CB B:GLN165 5.0 22.9 1.0

Reference:

S.Najmudin, M.L.Cote, D.Sun, S.Yohannan, S.P.Montano, J.Gu, M.M.Georgiadis. Crystal Structures of An N-Terminal Fragment From Moloney Murine Leukemia Virus Reverse Transcriptase Complexed with Nucleic Acid: Functional Implications For Template-Primer Binding to the Fingers Domain. J.Mol.Biol. V. 296 613 2000.
ISSN: ISSN 0022-2836
PubMed: 10669612
DOI: 10.1006/JMBI.1999.3477
Page generated: Sun Aug 11 01:11:41 2024

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