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Mercury in PDB 1zi4: Crystal Structure of Human N-Acetylgalactosaminyltransferase (Gta) Complexed with H Type II Trisaccharide

Enzymatic activity of Crystal Structure of Human N-Acetylgalactosaminyltransferase (Gta) Complexed with H Type II Trisaccharide

All present enzymatic activity of Crystal Structure of Human N-Acetylgalactosaminyltransferase (Gta) Complexed with H Type II Trisaccharide:
2.4.1.40;

Protein crystallography data

The structure of Crystal Structure of Human N-Acetylgalactosaminyltransferase (Gta) Complexed with H Type II Trisaccharide, PDB code: 1zi4 was solved by J.A.Letts, N.L.Rose, Y.R.Fang, C.H.Barry, S.N.Borisova, N.O.Seto, M.M.Palcic, S.V.Evans, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 20.00 / 1.85
Space group C 2 2 21
Cell size a, b, c (Å), α, β, γ (°) 52.400, 150.100, 79.200, 90.00, 90.00, 90.00
R / Rfree (%) 20.4 / 23.6

Other elements in 1zi4:

The structure of Crystal Structure of Human N-Acetylgalactosaminyltransferase (Gta) Complexed with H Type II Trisaccharide also contains other interesting chemical elements:

Chlorine (Cl) 1 atom

Mercury Binding Sites:

The binding sites of Mercury atom in the Crystal Structure of Human N-Acetylgalactosaminyltransferase (Gta) Complexed with H Type II Trisaccharide (pdb code 1zi4). This binding sites where shown within 5.0 Angstroms radius around Mercury atom.
In total 4 binding sites of Mercury where determined in the Crystal Structure of Human N-Acetylgalactosaminyltransferase (Gta) Complexed with H Type II Trisaccharide, PDB code: 1zi4:
Jump to Mercury binding site number: 1; 2; 3; 4;

Mercury binding site 1 out of 4 in 1zi4

Go back to Mercury Binding Sites List in 1zi4
Mercury binding site 1 out of 4 in the Crystal Structure of Human N-Acetylgalactosaminyltransferase (Gta) Complexed with H Type II Trisaccharide


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 1 of Crystal Structure of Human N-Acetylgalactosaminyltransferase (Gta) Complexed with H Type II Trisaccharide within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Hg401

b:40.5
occ:0.40
 SG A:CYS284 2.6 39.7 1.0
CB A:CYS284 3.1 32.0 1.0
CD2 A:LEU280 3.7 25.2 1.0
O A:ASP302 3.8 31.7 1.0
N A:LEU306 3.9 24.9 1.0
CA A:LEU306 3.9 24.8 1.0
CB A:LEU306 4.0 24.7 1.0
O A:HOH628 4.2 40.6 1.0
CD1 A:LEU306 4.5 27.8 1.0
C A:HIS305 4.5 26.1 1.0
CB A:HIS305 4.5 28.1 1.0
CA A:CYS284 4.6 32.1 1.0
C A:ASP302 4.6 32.9 1.0
O A:LEU280 4.8 25.5 1.0
CG A:LEU280 4.9 25.1 1.0
CG A:LEU306 4.9 26.3 1.0
CA A:ASP302 4.9 35.5 1.0
CB A:ASP302 4.9 39.3 1.0

Mercury binding site 2 out of 4 in 1zi4

Go back to Mercury Binding Sites List in 1zi4
Mercury binding site 2 out of 4 in the Crystal Structure of Human N-Acetylgalactosaminyltransferase (Gta) Complexed with H Type II Trisaccharide


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 2 of Crystal Structure of Human N-Acetylgalactosaminyltransferase (Gta) Complexed with H Type II Trisaccharide within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Hg403

b:36.1
occ:0.70
 SG A:CYS209 2.5 32.8 1.0
O A:HOH634 2.5 34.8 1.0
OG1 A:THR119 2.9 27.8 1.0
CB A:CYS209 3.3 25.3 1.0
CB A:THR119 3.8 26.9 1.0
CG2 A:THR119 3.9 26.3 1.0
CL A:CL402 3.9 42.9 1.0
CA A:CYS209 4.2 25.2 1.0
CG1 A:VAL277 4.3 21.6 1.0
N A:CYS209 4.7 24.3 1.0
CD1 A:LEU207 4.8 29.0 1.0
CZ A:PHE270 5.0 27.8 1.0
O A:VAL208 5.0 24.1 1.0

Mercury binding site 3 out of 4 in 1zi4

Go back to Mercury Binding Sites List in 1zi4
Mercury binding site 3 out of 4 in the Crystal Structure of Human N-Acetylgalactosaminyltransferase (Gta) Complexed with H Type II Trisaccharide


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 3 of Crystal Structure of Human N-Acetylgalactosaminyltransferase (Gta) Complexed with H Type II Trisaccharide within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Hg404

b:43.2
occ:0.50
 O A:GLY98 2.6 29.7 1.0
SG A:CYS80 2.8 58.7 1.0
CB A:CYS80 2.9 49.3 1.0
CA A:CYS80 3.0 47.6 1.0
O A:HOH564 3.5 37.0 1.0
C A:GLY98 3.8 29.9 1.0
C A:CYS80 4.0 45.9 1.0
N A:CYS80 4.1 46.6 1.0
O A:CYS80 4.2 46.1 1.0
CA A:THR99 4.3 26.4 1.0
O A:HOH571 4.4 41.8 1.0
N A:THR99 4.5 26.5 1.0
CA A:GLY98 4.8 28.3 1.0
C A:THR99 4.9 24.8 1.0
C A:PRO79 4.9 45.1 1.0
O A:THR99 5.0 24.5 1.0

Mercury binding site 4 out of 4 in 1zi4

Go back to Mercury Binding Sites List in 1zi4
Mercury binding site 4 out of 4 in the Crystal Structure of Human N-Acetylgalactosaminyltransferase (Gta) Complexed with H Type II Trisaccharide


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 4 of Crystal Structure of Human N-Acetylgalactosaminyltransferase (Gta) Complexed with H Type II Trisaccharide within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Hg405

b:33.8
occ:0.30
 O A:HOH626 2.6 35.2 1.0
SG A:CYS284 2.6 39.7 1.0
O A:HIS305 3.2 26.3 1.0
O A:HOH625 3.2 43.8 1.0
CA A:CYS284 3.4 32.1 1.0
CB A:TYR309 3.5 25.0 1.0
N A:CYS284 3.6 30.9 1.0
CB A:CYS284 3.6 32.0 1.0
C A:HIS305 3.8 26.1 1.0
C A:ALA283 3.9 30.9 1.0
CB A:HIS305 3.9 28.1 1.0
CD1 A:TYR309 4.0 26.9 1.0
O A:ALA283 4.1 32.5 1.0
CG A:TYR309 4.1 25.4 1.0
N A:TYR309 4.3 25.5 1.0
CA A:TYR309 4.3 25.0 1.0
CA A:HIS305 4.3 27.4 1.0
CB A:ALA283 4.3 28.3 1.0
O A:LEU280 4.6 25.5 1.0
CB A:ALA287 4.7 33.9 1.0
N A:LEU306 4.7 24.9 1.0
C A:CYS284 4.7 32.7 1.0
CA A:ALA283 4.8 30.5 1.0
CG A:HIS305 4.8 30.8 1.0
CD2 A:HIS305 5.0 29.5 1.0

Reference:

J.A.Letts, N.L.Rose, Y.R.Fang, C.H.Barry, S.N.Borisova, N.O.Seto, M.M.Palcic, S.V.Evans. Differential Recognition of the Type I and II H Antigen Acceptors By the Human Abo(H) Blood Group A and B Glycosyltransferases. J.Biol.Chem. V. 281 3625 2006.
ISSN: ISSN 0021-9258
PubMed: 16326711
DOI: 10.1074/JBC.M507620200
Page generated: Sun Aug 11 02:09:47 2024

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