Mercury in PDB 1zj1: Crystal Structure of Human Galactosyltransferase (Gtb) Complexed with N-Acetyllactosamine

The structure of Crystal Structure of Human Galactosyltransferase (Gtb) Complexed with N-Acetyllactosamine, PDB code: 1zj1 was solved by J.A.Letts, N.L.Rose, Y.R.Fang, C.H.Barry, S.N.Borisova, N.O.Seto, M.M.Palcic, S.V.Evans, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	20.00 / 1.65
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	52.430, 149.960, 79.460, 90.00, 90.00, 90.00
R / Rfree (%)	20.4 / 22.6

The structure of Crystal Structure of Human Galactosyltransferase (Gtb) Complexed with N-Acetyllactosamine also contains other interesting chemical elements:

Chlorine

(Cl)

1 atom

The binding sites of Mercury atom in the Crystal Structure of Human Galactosyltransferase (Gtb) Complexed with N-Acetyllactosamine (pdb code 1zj1). This binding sites where shown within 5.0 Angstroms radius around Mercury atom.
In total 4 binding sites of Mercury where determined in the Crystal Structure of Human Galactosyltransferase (Gtb) Complexed with N-Acetyllactosamine, PDB code: 1zj1:
Jump to Mercury binding site number: 1; 2; 3; 4;

Mercury binding site 1 out of 4 in the Crystal Structure of Human Galactosyltransferase (Gtb) Complexed with N-Acetyllactosamine


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 1 of Crystal Structure of Human Galactosyltransferase (Gtb) Complexed with N-Acetyllactosamine within 5.0Å range: probe atom residue distance (Å) B Occ A:Hg401 b:30.7 occ:0.50 SG A:CYS284 2.9 35.7 1.0 CB A:CYS284 3.0 26.8 1.0 CD2 A:LEU280 3.4 19.3 1.0 CA A:LEU306 3.9 15.8 1.0 CB A:LEU306 3.9 16.1 1.0 O A:ASP302 3.9 22.6 1.0 N A:LEU306 4.0 16.4 1.0 CD1 A:LEU306 4.4 17.7 1.0 CA A:CYS284 4.4 23.7 1.0 CG A:LEU280 4.5 19.4 1.0 O A:LEU280 4.5 19.3 1.0 C A:HIS305 4.6 17.8 1.0 CB A:HIS305 4.8 20.6 1.0 CG A:LEU306 4.8 18.0 1.0 O A:HOH501 4.8 11.8 1.0 C A:ASP302 4.9 24.0 1.0 HG A:HG405 4.9 36.0 0.3 CB A:ASP302 5.0 30.1 1.0

Mercury binding site 2 out of 4 in the Crystal Structure of Human Galactosyltransferase (Gtb) Complexed with N-Acetyllactosamine


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 2 of Crystal Structure of Human Galactosyltransferase (Gtb) Complexed with N-Acetyllactosamine within 5.0Å range: probe atom residue distance (Å) B Occ A:Hg402 b:27.4 occ:0.70 SG A:CYS209 2.4 23.0 1.0 O A:HOH508 2.7 49.6 1.0 OG1 A:THR119 2.9 23.4 1.0 CB A:CYS209 3.3 18.7 1.0 O A:HOH627 3.8 22.3 1.0 CB A:THR119 3.9 19.9 1.0 CG2 A:THR119 4.0 23.2 1.0 CA A:CYS209 4.2 17.1 1.0 CG1 A:VAL277 4.3 17.6 1.0 N A:CYS209 4.8 16.2 1.0 CD1 A:LEU207 4.9 22.3 1.0 CZ A:PHE270 4.9 19.2 1.0 CE1 A:PHE270 5.0 18.6 1.0

Mercury binding site 3 out of 4 in the Crystal Structure of Human Galactosyltransferase (Gtb) Complexed with N-Acetyllactosamine


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 3 of Crystal Structure of Human Galactosyltransferase (Gtb) Complexed with N-Acetyllactosamine within 5.0Å range: probe atom residue distance (Å) B Occ A:Hg403 b:30.4 occ:0.40 O A:GLY98 2.7 22.6 1.0 SG A:CYS80 2.7 47.7 1.0 CB A:CYS80 2.9 42.4 1.0 CA A:CYS80 3.0 39.8 1.0 C A:CYS80 3.8 38.2 1.0 C A:GLY98 3.8 21.3 1.0 O A:CYS80 3.8 38.4 1.0 O A:HOH604 4.2 43.0 1.0 N A:CYS80 4.2 39.5 1.0 CA A:THR99 4.3 18.2 1.0 O A:HOH633 4.4 37.7 1.0 N A:THR99 4.5 18.0 1.0 CA A:GLY98 4.8 19.9 1.0 N A:ARG81 4.9 35.8 1.0 C A:THR99 4.9 18.9 1.0

Mercury binding site 4 out of 4 in the Crystal Structure of Human Galactosyltransferase (Gtb) Complexed with N-Acetyllactosamine


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 4 of Crystal Structure of Human Galactosyltransferase (Gtb) Complexed with N-Acetyllactosamine within 5.0Å range: probe atom residue distance (Å) B Occ A:Hg405 b:36.0 occ:0.30 SG A:CYS284 2.8 35.7 1.0 SD A:MET288 2.9 37.6 1.0 CB A:CYS284 3.7 26.8 1.0 N A:HIS285 3.7 24.9 1.0 C A:CYS284 3.8 23.7 1.0 CA A:HIS285 3.9 26.1 1.0 O A:CYS284 3.9 24.6 1.0 CG A:MET288 4.0 29.3 1.0 CA A:CYS284 4.4 23.7 1.0 CB A:ASP302 4.5 30.1 1.0 CE A:MET288 4.5 35.5 1.0 CB A:HIS285 4.6 28.4 1.0 CB A:MET288 4.7 27.0 1.0 O A:THR281 4.9 21.8 1.0 HG A:HG401 4.9 30.7 0.5

J.A.Letts, N.L.Rose, Y.R.Fang, C.H.Barry, S.N.Borisova, N.O.Seto, M.M.Palcic, S.V.Evans. Differential Recognition of the Type I and II H Antigen Acceptors By the Human Abo(H) Blood Group A and B Glycosyltransferases. J.Biol.Chem. V. 281 3625 2006.
ISSN: ISSN 0021-9258
PubMed: 16326711
DOI: 10.1074/JBC.M507620200