Mercury in PDB 1zj2: Crystal Structure of Human Galactosyltransferase (Gtb) Complexed with H Type I Trisaccharide

The structure of Crystal Structure of Human Galactosyltransferase (Gtb) Complexed with H Type I Trisaccharide, PDB code: 1zj2 was solved by J.A.Letts, N.L.Rose, Y.R.Fang, C.H.Barry, S.N.Borisova, N.O.Seto, M.M.Palcic, S.V.Evans, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	20.00 / 1.69
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	52.600, 150.430, 79.610, 90.00, 90.00, 90.00
R / Rfree (%)	20.6 / 23.2

The structure of Crystal Structure of Human Galactosyltransferase (Gtb) Complexed with H Type I Trisaccharide also contains other interesting chemical elements:

Manganese	(Mn)	1 atom
Chlorine	(Cl)	1 atom

The binding sites of Mercury atom in the Crystal Structure of Human Galactosyltransferase (Gtb) Complexed with H Type I Trisaccharide (pdb code 1zj2). This binding sites where shown within 5.0 Angstroms radius around Mercury atom.
In total 6 binding sites of Mercury where determined in the Crystal Structure of Human Galactosyltransferase (Gtb) Complexed with H Type I Trisaccharide, PDB code: 1zj2:
Jump to Mercury binding site number: 1; 2; 3; 4; 5; 6;

Mercury binding site 1 out of 6 in the Crystal Structure of Human Galactosyltransferase (Gtb) Complexed with H Type I Trisaccharide


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 1 of Crystal Structure of Human Galactosyltransferase (Gtb) Complexed with H Type I Trisaccharide within 5.0Å range: probe atom residue distance (Å) B Occ A:Hg401 b:32.0 occ:0.40 SG A:CYS284 2.4 31.2 1.0 CB A:CYS284 3.1 27.7 1.0 CD2 A:LEU280 3.6 22.8 1.0 N A:LEU306 3.7 20.0 1.0 CA A:LEU306 3.7 18.9 1.0 O A:ASP302 3.7 25.8 1.0 CB A:LEU306 3.8 19.1 1.0 C A:HIS305 4.3 21.5 1.0 CD1 A:LEU306 4.4 19.2 1.0 CB A:HIS305 4.5 25.3 1.0 CA A:CYS284 4.6 27.7 1.0 CG A:LEU280 4.7 19.6 1.0 C A:ASP302 4.7 27.4 1.0 O A:LEU280 4.7 20.3 1.0 CG A:LEU306 4.8 18.8 1.0 HG A:HG403 4.8 28.4 0.3 O A:HIS305 4.8 21.7 1.0 HG A:HG408 4.9 40.2 0.2

Mercury binding site 2 out of 6 in the Crystal Structure of Human Galactosyltransferase (Gtb) Complexed with H Type I Trisaccharide


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 2 of Crystal Structure of Human Galactosyltransferase (Gtb) Complexed with H Type I Trisaccharide within 5.0Å range: probe atom residue distance (Å) B Occ A:Hg402 b:27.6 occ:0.60 SG A:CYS209 2.4 25.7 1.0 OG1 A:THR119 2.8 23.9 1.0 CB A:CYS209 3.2 20.6 1.0 HG A:HG405 3.5 35.0 0.2 CB A:THR119 3.9 21.1 1.0 CG2 A:THR119 4.1 21.3 1.0 CA A:CYS209 4.1 19.0 1.0 CG1 A:VAL277 4.4 17.8 1.0 N A:CYS209 4.7 18.8 1.0 CD1 A:LEU207 4.8 24.0 1.0 O A:VAL208 5.0 20.3 1.0

Mercury binding site 3 out of 6 in the Crystal Structure of Human Galactosyltransferase (Gtb) Complexed with H Type I Trisaccharide


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 3 of Crystal Structure of Human Galactosyltransferase (Gtb) Complexed with H Type I Trisaccharide within 5.0Å range: probe atom residue distance (Å) B Occ A:Hg403 b:28.4 occ:0.35 SG A:CYS284 2.5 31.2 1.0 O A:HIS305 3.2 21.7 1.0 CA A:CYS284 3.3 27.7 1.0 N A:CYS284 3.4 25.6 1.0 CB A:CYS284 3.5 27.7 1.0 CB A:TYR309 3.5 20.1 1.0 C A:HIS305 3.8 21.5 1.0 C A:ALA283 3.9 25.1 1.0 CB A:HIS305 3.9 25.3 1.0 CD1 A:TYR309 4.0 19.6 1.0 O A:ALA283 4.1 26.4 1.0 CG A:TYR309 4.2 17.5 1.0 CB A:ALA283 4.2 22.4 1.0 CA A:HIS305 4.3 22.9 1.0 N A:TYR309 4.3 19.0 1.0 CA A:TYR309 4.3 19.6 1.0 O A:LEU280 4.6 20.3 1.0 CB A:ALA287 4.6 30.7 1.0 N A:LEU306 4.7 20.0 1.0 C A:CYS284 4.7 28.7 1.0 CA A:ALA283 4.7 24.3 1.0 CG A:HIS305 4.8 27.0 1.0 HG A:HG401 4.8 32.0 0.4 CD2 A:HIS305 4.9 27.1 1.0

Mercury binding site 4 out of 6 in the Crystal Structure of Human Galactosyltransferase (Gtb) Complexed with H Type I Trisaccharide


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 4 of Crystal Structure of Human Galactosyltransferase (Gtb) Complexed with H Type I Trisaccharide within 5.0Å range: probe atom residue distance (Å) B Occ A:Hg404 b:35.5 occ:0.40 O A:GLY98 2.6 24.6 1.0 CB A:CYS80 2.8 47.7 1.0 CA A:CYS80 2.8 45.7 1.0 SG A:CYS80 2.9 56.2 1.0 C A:GLY98 3.7 22.9 1.0 C A:CYS80 3.8 43.4 1.0 N A:CYS80 3.9 45.0 1.0 O A:HOH620 3.9 45.0 1.0 O A:CYS80 4.1 43.9 1.0 CA A:THR99 4.3 19.8 1.0 O A:HOH644 4.4 41.0 1.0 N A:THR99 4.5 20.4 1.0 C A:PRO79 4.8 44.1 1.0 CA A:GLY98 4.8 22.7 1.0 N A:ARG81 4.8 41.9 1.0 O A:PRO79 4.9 43.8 1.0 C A:THR99 4.9 20.6 1.0

Mercury binding site 5 out of 6 in the Crystal Structure of Human Galactosyltransferase (Gtb) Complexed with H Type I Trisaccharide


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 5 of Crystal Structure of Human Galactosyltransferase (Gtb) Complexed with H Type I Trisaccharide within 5.0Å range: probe atom residue distance (Å) B Occ A:Hg405 b:35.0 occ:0.20 OG1 A:THR119 2.8 23.9 1.0 CL A:CL407 2.9 25.7 0.5 CE1 A:PHE121 3.1 35.1 1.0 CD1 A:PHE121 3.4 34.0 1.0 HG A:HG402 3.5 27.6 0.6 O A:THR119 3.5 21.9 1.0 CB A:CYS209 3.6 20.6 1.0 CB A:THR119 3.7 21.1 1.0 C A:THR119 3.8 21.0 1.0 CA A:CYS209 4.0 19.0 1.0 N A:VAL120 4.4 21.2 1.0 CZ A:PHE121 4.4 35.5 1.0 N A:VAL210 4.4 18.9 1.0 CA A:THR119 4.4 21.1 1.0 C A:CYS209 4.5 18.6 1.0 SG A:CYS209 4.5 25.7 1.0 O A:HOH523 4.5 30.0 1.0 CA A:VAL120 4.6 20.9 1.0 O A:VAL210 4.6 19.3 1.0 CG A:PHE121 4.8 32.3 1.0 CG2 A:THR119 4.9 21.3 1.0 C A:VAL120 5.0 22.7 1.0

Mercury binding site 6 out of 6 in the Crystal Structure of Human Galactosyltransferase (Gtb) Complexed with H Type I Trisaccharide


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 6 of Crystal Structure of Human Galactosyltransferase (Gtb) Complexed with H Type I Trisaccharide within 5.0Å range: probe atom residue distance (Å) B Occ A:Hg408 b:40.2 occ:0.20 SD A:MET288 2.7 41.7 1.0 OD1 A:ASP302 3.4 41.9 1.0 C A:CYS284 3.7 28.7 1.0 CB A:CYS284 3.7 27.7 1.0 N A:HIS285 3.8 28.9 1.0 O A:CYS284 3.8 30.0 1.0 CG A:MET288 3.8 36.7 1.0 CA A:HIS285 3.9 31.6 1.0 CE A:MET288 4.3 40.7 1.0 CA A:CYS284 4.4 27.7 1.0 CG A:ASP302 4.5 38.4 1.0 CB A:MET288 4.6 33.3 1.0 CB A:HIS285 4.7 34.7 1.0 HG A:HG401 4.9 32.0 0.4 O A:THR281 4.9 23.0 1.0

J.A.Letts, N.L.Rose, Y.R.Fang, C.H.Barry, S.N.Borisova, N.O.Seto, M.M.Palcic, S.V.Evans. Differential Recognition of the Type I and II H Antigen Acceptors By the Human Abo(H) Blood Group A and B Glycosyltransferases. J.Biol.Chem. V. 281 3625 2006.
ISSN: ISSN 0021-9258
PubMed: 16326711
DOI: 10.1074/JBC.M507620200