Mercury in PDB 1zj3: Crystal Structure of Human Galactosyltransferase (Gtb) Complexed with H Type II Trisaccharide

The structure of Crystal Structure of Human Galactosyltransferase (Gtb) Complexed with H Type II Trisaccharide, PDB code: 1zj3 was solved by J.A.Letts, N.L.Rose, Y.R.Fang, C.H.Barry, S.N.Borisova, N.O.Seto, M.M.Palcic, S.V.Evans, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	20.00 / 1.69
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	52.600, 150.800, 79.700, 90.00, 90.00, 90.00
R / Rfree (%)	20.4 / 23

The structure of Crystal Structure of Human Galactosyltransferase (Gtb) Complexed with H Type II Trisaccharide also contains other interesting chemical elements:

Chlorine

(Cl)

2 atoms

The binding sites of Mercury atom in the Crystal Structure of Human Galactosyltransferase (Gtb) Complexed with H Type II Trisaccharide (pdb code 1zj3). This binding sites where shown within 5.0 Angstroms radius around Mercury atom.
In total 6 binding sites of Mercury where determined in the Crystal Structure of Human Galactosyltransferase (Gtb) Complexed with H Type II Trisaccharide, PDB code: 1zj3:
Jump to Mercury binding site number: 1; 2; 3; 4; 5; 6;

Mercury binding site 1 out of 6 in the Crystal Structure of Human Galactosyltransferase (Gtb) Complexed with H Type II Trisaccharide


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 1 of Crystal Structure of Human Galactosyltransferase (Gtb) Complexed with H Type II Trisaccharide within 5.0Å range: probe atom residue distance (Å) B Occ A:Hg401 b:31.0 occ:0.40 SG A:CYS284 2.4 32.5 1.0 CB A:CYS284 3.1 28.9 1.0 CD2 A:LEU280 3.6 21.6 1.0 O A:ASP302 3.7 26.1 1.0 N A:LEU306 3.8 18.7 1.0 CA A:LEU306 3.8 18.5 1.0 CB A:LEU306 3.9 18.8 1.0 C A:HIS305 4.4 20.6 1.0 CD1 A:LEU306 4.4 19.9 1.0 CB A:HIS305 4.5 23.9 1.0 CA A:CYS284 4.6 27.7 1.0 C A:ASP302 4.7 26.8 1.0 CG A:LEU280 4.7 19.1 1.0 CG A:LEU306 4.8 19.2 1.0 O A:LEU280 4.8 21.3 1.0 HG A:HG408 4.8 44.4 0.2 O A:HIS305 4.8 21.5 1.0 HG A:HG403 4.8 27.8 0.3 CB A:ASP302 5.0 33.8 1.0 CA A:ASP302 5.0 29.3 1.0

Mercury binding site 2 out of 6 in the Crystal Structure of Human Galactosyltransferase (Gtb) Complexed with H Type II Trisaccharide


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 2 of Crystal Structure of Human Galactosyltransferase (Gtb) Complexed with H Type II Trisaccharide within 5.0Å range: probe atom residue distance (Å) B Occ A:Hg402 b:27.5 occ:0.50 SG A:CYS209 2.4 28.9 1.0 CL A:CL406 2.5 36.8 0.6 OG1 A:THR119 2.8 25.3 1.0 CB A:CYS209 3.3 21.0 1.0 HG A:HG405 3.7 29.4 0.2 CB A:THR119 3.8 23.0 1.0 CG2 A:THR119 4.0 24.2 1.0 CA A:CYS209 4.2 19.2 1.0 CG1 A:VAL277 4.3 16.6 1.0 N A:CYS209 4.7 18.5 1.0 CD1 A:LEU207 4.8 23.6 1.0 O A:VAL208 4.9 19.7 1.0 C A:VAL208 5.0 18.7 1.0

Mercury binding site 3 out of 6 in the Crystal Structure of Human Galactosyltransferase (Gtb) Complexed with H Type II Trisaccharide


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 3 of Crystal Structure of Human Galactosyltransferase (Gtb) Complexed with H Type II Trisaccharide within 5.0Å range: probe atom residue distance (Å) B Occ A:Hg403 b:27.8 occ:0.30 SG A:CYS284 2.5 32.5 1.0 O A:HIS305 3.2 21.5 1.0 CA A:CYS284 3.3 27.7 1.0 N A:CYS284 3.4 26.1 1.0 CB A:CYS284 3.5 28.9 1.0 CB A:TYR309 3.5 19.5 1.0 C A:ALA283 3.8 25.9 1.0 C A:HIS305 3.9 20.6 1.0 CB A:HIS305 3.9 23.9 1.0 CD1 A:TYR309 4.0 19.6 1.0 O A:ALA283 4.0 27.1 1.0 CG A:TYR309 4.2 18.2 1.0 CB A:ALA283 4.2 23.6 1.0 CA A:HIS305 4.3 22.1 1.0 CA A:TYR309 4.3 19.9 1.0 N A:TYR309 4.3 20.6 1.0 O A:LEU280 4.6 21.3 1.0 CB A:ALA287 4.6 28.9 1.0 C A:CYS284 4.7 28.7 1.0 CA A:ALA283 4.7 25.3 1.0 N A:LEU306 4.7 18.7 1.0 CG A:HIS305 4.8 25.9 1.0 HG A:HG401 4.8 31.0 0.4 CD2 A:HIS305 4.9 27.4 1.0

Mercury binding site 4 out of 6 in the Crystal Structure of Human Galactosyltransferase (Gtb) Complexed with H Type II Trisaccharide


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 4 of Crystal Structure of Human Galactosyltransferase (Gtb) Complexed with H Type II Trisaccharide within 5.0Å range: probe atom residue distance (Å) B Occ A:Hg404 b:32.8 occ:0.40 O A:GLY98 2.6 23.0 1.0 CB A:CYS80 2.8 47.7 1.0 CA A:CYS80 2.8 45.7 1.0 SG A:CYS80 2.9 56.7 1.0 C A:GLY98 3.7 21.5 1.0 O A:HOH632 3.7 34.5 1.0 O A:HOH650 3.8 47.9 1.0 C A:CYS80 3.8 43.4 1.0 N A:CYS80 3.9 45.1 1.0 O A:CYS80 4.1 43.9 1.0 O A:HOH636 4.2 44.7 1.0 CA A:THR99 4.3 19.2 1.0 O A:HOH597 4.3 37.0 1.0 N A:THR99 4.4 19.2 1.0 CA A:GLY98 4.7 22.1 1.0 C A:PRO79 4.8 44.1 1.0 N A:ARG81 4.9 41.8 1.0 O A:PRO79 4.9 43.5 1.0 C A:THR99 4.9 20.4 1.0

Mercury binding site 5 out of 6 in the Crystal Structure of Human Galactosyltransferase (Gtb) Complexed with H Type II Trisaccharide


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 5 of Crystal Structure of Human Galactosyltransferase (Gtb) Complexed with H Type II Trisaccharide within 5.0Å range: probe atom residue distance (Å) B Occ A:Hg405 b:29.4 occ:0.20 CL A:CL407 2.8 27.4 0.5 OG1 A:THR119 3.0 25.3 1.0 CL A:CL406 3.1 36.8 0.6 CE1 A:PHE121 3.2 37.1 1.0 CD1 A:PHE121 3.3 36.9 1.0 O A:THR119 3.6 21.4 1.0 CB A:CYS209 3.7 21.0 1.0 HG A:HG402 3.7 27.5 0.5 CB A:THR119 3.8 23.0 1.0 C A:THR119 3.9 20.7 1.0 CA A:CYS209 4.1 19.2 1.0 O A:HOH547 4.2 29.8 1.0 N A:VAL120 4.3 21.6 1.0 O A:VAL210 4.3 19.5 1.0 N A:VAL210 4.4 18.8 1.0 CA A:VAL120 4.4 21.5 1.0 CZ A:PHE121 4.5 38.5 1.0 C A:CYS209 4.5 18.8 1.0 CA A:THR119 4.5 21.5 1.0 SG A:CYS209 4.6 28.9 1.0 CG A:PHE121 4.7 34.6 1.0 N A:PHE121 4.8 23.0 1.0 C A:VAL120 4.9 23.9 1.0

Mercury binding site 6 out of 6 in the Crystal Structure of Human Galactosyltransferase (Gtb) Complexed with H Type II Trisaccharide


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 6 of Crystal Structure of Human Galactosyltransferase (Gtb) Complexed with H Type II Trisaccharide within 5.0Å range: probe atom residue distance (Å) B Occ A:Hg408 b:44.4 occ:0.20 SD A:MET288 2.8 40.4 1.0 OD2 A:ASP302 3.4 40.0 1.0 CB A:CYS284 3.8 28.9 1.0 N A:HIS285 3.8 28.7 1.0 C A:CYS284 3.8 28.7 1.0 CG A:MET288 3.9 35.4 1.0 O A:CYS284 4.0 28.9 1.0 CA A:HIS285 4.0 32.0 1.0 CE A:MET288 4.3 39.3 1.0 CG A:ASP302 4.3 37.8 1.0 CA A:CYS284 4.5 27.7 1.0 CB A:HIS285 4.7 35.4 1.0 CB A:MET288 4.7 32.7 1.0 HG A:HG401 4.8 31.0 0.4 O A:THR281 4.9 24.8 1.0 CB A:ASP302 4.9 33.8 1.0

J.A.Letts, N.L.Rose, Y.R.Fang, C.H.Barry, S.N.Borisova, N.O.Seto, M.M.Palcic, S.V.Evans. Differential Recognition of the Type I and II H Antigen Acceptors By the Human Abo(H) Blood Group A and B Glycosyltransferases. J.Biol.Chem. V. 281 3625 2006.
ISSN: ISSN 0021-9258
PubMed: 16326711
DOI: 10.1074/JBC.M507620200