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Mercury in PDB 1zjo: Crystal Structure of Human N-Acetylgalactosaminyltransferase (Gta) Complexed with Galactose-Grease

Enzymatic activity of Crystal Structure of Human N-Acetylgalactosaminyltransferase (Gta) Complexed with Galactose-Grease

All present enzymatic activity of Crystal Structure of Human N-Acetylgalactosaminyltransferase (Gta) Complexed with Galactose-Grease:
2.4.1.40;

Protein crystallography data

The structure of Crystal Structure of Human N-Acetylgalactosaminyltransferase (Gta) Complexed with Galactose-Grease, PDB code: 1zjo was solved by J.A.Letts, N.L.Rose, Y.R.Fang, C.H.Barry, S.N.Borisova, N.O.Seto, M.M.Palcic, S.V.Evans, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 20.00 / 1.64
Space group C 2 2 21
Cell size a, b, c (Å), α, β, γ (°) 52.570, 149.570, 79.390, 90.00, 90.00, 90.00
R / Rfree (%) 20.6 / 22.6

Other elements in 1zjo:

The structure of Crystal Structure of Human N-Acetylgalactosaminyltransferase (Gta) Complexed with Galactose-Grease also contains other interesting chemical elements:

Manganese (Mn) 1 atom
Chlorine (Cl) 2 atoms

Mercury Binding Sites:

The binding sites of Mercury atom in the Crystal Structure of Human N-Acetylgalactosaminyltransferase (Gta) Complexed with Galactose-Grease (pdb code 1zjo). This binding sites where shown within 5.0 Angstroms radius around Mercury atom.
In total 5 binding sites of Mercury where determined in the Crystal Structure of Human N-Acetylgalactosaminyltransferase (Gta) Complexed with Galactose-Grease, PDB code: 1zjo:
Jump to Mercury binding site number: 1; 2; 3; 4; 5;

Mercury binding site 1 out of 5 in 1zjo

Go back to Mercury Binding Sites List in 1zjo
Mercury binding site 1 out of 5 in the Crystal Structure of Human N-Acetylgalactosaminyltransferase (Gta) Complexed with Galactose-Grease


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 1 of Crystal Structure of Human N-Acetylgalactosaminyltransferase (Gta) Complexed with Galactose-Grease within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Hg401

b:32.5
occ:0.35
 O A:HOH734 2.4 33.9 1.0
SG A:CYS284 2.5 27.1 1.0
CB A:CYS284 3.1 23.5 1.0
CD2 A:LEU280 3.6 18.1 1.0
O A:ASP302 3.8 23.2 1.0
N A:LEU306 3.8 17.2 1.0
CA A:LEU306 3.8 17.9 1.0
CB A:LEU306 3.9 18.4 1.0
C A:HIS305 4.4 18.4 1.0
CD1 A:LEU306 4.5 22.6 1.0
CB A:HIS305 4.6 21.5 1.0
CA A:CYS284 4.6 23.6 1.0
CG A:LEU280 4.7 17.9 1.0
C A:ASP302 4.7 24.1 1.0
O A:LEU280 4.7 19.5 1.0
HG A:HG407 4.8 34.6 0.2
CG A:LEU306 4.9 20.6 1.0
HG A:HG405 4.9 22.9 0.4
CB A:ASP302 4.9 30.3 1.0
O A:HIS305 4.9 17.1 1.0
CA A:ASP302 5.0 26.0 1.0

Mercury binding site 2 out of 5 in 1zjo

Go back to Mercury Binding Sites List in 1zjo
Mercury binding site 2 out of 5 in the Crystal Structure of Human N-Acetylgalactosaminyltransferase (Gta) Complexed with Galactose-Grease


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 2 of Crystal Structure of Human N-Acetylgalactosaminyltransferase (Gta) Complexed with Galactose-Grease within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Hg403

b:30.7
occ:0.70
 O A:HOH729 2.3 19.0 1.0
O A:HOH728 2.4 27.0 1.0
SG A:CYS209 2.4 26.8 1.0
OG1 A:THR119 2.9 23.3 1.0
CB A:CYS209 3.2 19.9 1.0
CL A:CL402 3.7 33.3 1.0
CB A:THR119 3.9 17.5 1.0
CG2 A:THR119 4.0 21.2 1.0
CA A:CYS209 4.1 17.0 1.0
CG1 A:VAL277 4.3 16.6 1.0
N A:CYS209 4.6 17.0 1.0
CD1 A:LEU207 4.9 22.7 1.0
CZ A:PHE270 5.0 18.0 1.0
CE1 A:PHE270 5.0 18.4 1.0
O A:VAL208 5.0 16.8 1.0

Mercury binding site 3 out of 5 in 1zjo

Go back to Mercury Binding Sites List in 1zjo
Mercury binding site 3 out of 5 in the Crystal Structure of Human N-Acetylgalactosaminyltransferase (Gta) Complexed with Galactose-Grease


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 3 of Crystal Structure of Human N-Acetylgalactosaminyltransferase (Gta) Complexed with Galactose-Grease within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Hg404

b:31.9
occ:0.40
 O A:HOH716 2.3 29.7 1.0
O A:GLY98 2.8 22.1 1.0
SG A:CYS80 2.8 50.3 1.0
CB A:CYS80 2.9 43.1 1.0
CA A:CYS80 3.0 40.1 1.0
O A:HOH715 3.3 32.5 1.0
O A:HOH701 3.4 43.3 1.0
C A:CYS80 3.9 38.1 1.0
C A:GLY98 3.9 19.7 1.0
O A:CYS80 4.0 38.1 1.0
N A:CYS80 4.1 39.5 1.0
CA A:THR99 4.3 17.7 1.0
O A:HOH609 4.5 37.9 1.0
N A:THR99 4.6 17.1 1.0
O A:HOH697 4.8 49.3 1.0
C A:THR99 4.9 17.4 1.0
C A:PRO79 5.0 38.3 1.0
O A:THR99 5.0 19.1 1.0
N A:ARG81 5.0 36.0 1.0
O A:PRO79 5.0 38.0 1.0

Mercury binding site 4 out of 5 in 1zjo

Go back to Mercury Binding Sites List in 1zjo
Mercury binding site 4 out of 5 in the Crystal Structure of Human N-Acetylgalactosaminyltransferase (Gta) Complexed with Galactose-Grease


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 4 of Crystal Structure of Human N-Acetylgalactosaminyltransferase (Gta) Complexed with Galactose-Grease within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Hg405

b:22.9
occ:0.40
 SG A:CYS284 2.5 27.1 1.0
O A:HOH732 2.5 31.2 1.0
O A:HIS305 3.2 17.1 1.0
CA A:CYS284 3.3 23.6 1.0
N A:CYS284 3.4 21.3 1.0
CB A:CYS284 3.5 23.5 1.0
CB A:TYR309 3.6 15.2 1.0
O A:HOH733 3.6 31.1 1.0
C A:HIS305 3.8 18.4 1.0
C A:ALA283 3.8 22.0 1.0
CB A:HIS305 3.9 21.5 1.0
CD1 A:TYR309 4.1 14.3 1.0
O A:ALA283 4.1 21.9 1.0
CG A:TYR309 4.2 14.4 1.0
CB A:ALA283 4.2 19.6 1.0
N A:TYR309 4.3 16.5 1.0
CA A:HIS305 4.3 19.3 1.0
CA A:TYR309 4.3 15.4 1.0
O A:LEU280 4.5 19.5 1.0
N A:LEU306 4.7 17.2 1.0
C A:CYS284 4.7 24.0 1.0
CA A:ALA283 4.7 21.1 1.0
CB A:ALA287 4.7 27.0 1.0
CG A:HIS305 4.8 23.5 1.0
HG A:HG401 4.9 32.5 0.3
CD2 A:HIS305 5.0 24.2 1.0

Mercury binding site 5 out of 5 in 1zjo

Go back to Mercury Binding Sites List in 1zjo
Mercury binding site 5 out of 5 in the Crystal Structure of Human N-Acetylgalactosaminyltransferase (Gta) Complexed with Galactose-Grease


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 5 of Crystal Structure of Human N-Acetylgalactosaminyltransferase (Gta) Complexed with Galactose-Grease within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Hg407

b:34.6
occ:0.20
 SD A:MET288 2.7 38.8 1.0
OD2 A:ASP302 3.4 38.2 1.0
CB A:CYS284 3.7 23.5 1.0
C A:CYS284 3.7 24.0 1.0
N A:HIS285 3.7 24.4 1.0
O A:CYS284 3.8 25.4 1.0
CG A:MET288 3.8 32.5 1.0
CA A:HIS285 3.9 26.9 1.0
CE A:MET288 4.3 37.7 1.0
CG A:ASP302 4.3 33.9 1.0
CA A:CYS284 4.3 23.6 1.0
CB A:MET288 4.6 29.6 1.0
CB A:HIS285 4.6 29.4 1.0
HG A:HG401 4.8 32.5 0.3
O A:THR281 4.8 21.4 1.0
OD1 A:ASP302 5.0 37.0 1.0

Reference:

J.A.Letts, N.L.Rose, Y.R.Fang, C.H.Barry, S.N.Borisova, N.O.Seto, M.M.Palcic, S.V.Evans. Differential Recognition of the Type I and II H Antigen Acceptors By the Human Abo(H) Blood Group A and B Glycosyltransferases. J.Biol.Chem. V. 281 3625 2006.
ISSN: ISSN 0021-9258
PubMed: 16326711
DOI: 10.1074/JBC.M507620200
Page generated: Fri Aug 8 09:43:57 2025

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