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Mercury in PDB 2cfp: Sugar Free Lactose Permease at Acidic pH

Protein crystallography data

The structure of Sugar Free Lactose Permease at Acidic pH, PDB code: 2cfp was solved by O.Mirza, L.Guan, G.Verner, S.Iwata, H.R.Kaback, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 14.98 / 3.3
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 123.920, 123.920, 190.850, 90.00, 90.00, 90.00
R / Rfree (%) 28.6 / 32.8

Mercury Binding Sites:

The binding sites of Mercury atom in the Sugar Free Lactose Permease at Acidic pH (pdb code 2cfp). This binding sites where shown within 5.0 Angstroms radius around Mercury atom.
In total 5 binding sites of Mercury where determined in the Sugar Free Lactose Permease at Acidic pH, PDB code: 2cfp:
Jump to Mercury binding site number: 1; 2; 3; 4; 5;

Mercury binding site 1 out of 5 in 2cfp

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Mercury binding site 1 out of 5 in the Sugar Free Lactose Permease at Acidic pH


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 1 of Sugar Free Lactose Permease at Acidic pH within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Hg501

b:0.5
occ:0.47
SG A:CYS148 3.1 73.0 1.0
CB A:CYS148 3.9 66.5 1.0
CE A:MET145 4.1 82.4 1.0
SD A:MET145 4.3 80.6 1.0
CB A:ALA273 4.9 66.4 1.0

Mercury binding site 2 out of 5 in 2cfp

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Mercury binding site 2 out of 5 in the Sugar Free Lactose Permease at Acidic pH


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 2 of Sugar Free Lactose Permease at Acidic pH within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Hg502

b:84.7
occ:0.44
SG A:CYS176 2.4 47.6 1.0
O A:LEU172 2.7 38.9 1.0
CD2 A:PHE21 2.9 43.7 1.0
CB A:CYS176 3.1 57.0 1.0
C A:LEU172 3.4 39.8 1.0
CD1 A:ILE22 3.5 16.0 1.0
CE2 A:PHE21 3.6 44.1 1.0
O A:PHE21 3.7 28.4 1.0
C A:PHE21 3.8 30.8 1.0
CG A:PHE21 3.9 40.9 1.0
CA A:ILE22 3.9 24.9 1.0
N A:ILE22 3.9 28.8 1.0
CG1 A:ILE22 4.0 18.4 1.0
CA A:GLY173 4.0 40.2 1.0
N A:GLY173 4.0 39.7 1.0
CB A:LEU172 4.1 42.4 1.0
CB A:PHE21 4.1 36.0 1.0
N A:ALA177 4.2 52.9 1.0
CA A:CYS176 4.3 55.0 1.0
CA A:LEU172 4.3 41.1 1.0
C A:CYS176 4.4 54.4 1.0
CB A:ALA177 4.4 50.0 1.0
CB A:ILE22 4.6 21.7 1.0
CA A:PHE21 4.6 35.0 1.0
C A:GLY173 4.8 41.2 1.0
O A:GLY173 4.8 39.8 1.0
CZ A:PHE21 4.8 44.8 1.0
CA A:ALA177 4.8 52.5 1.0

Mercury binding site 3 out of 5 in 2cfp

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Mercury binding site 3 out of 5 in the Sugar Free Lactose Permease at Acidic pH


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 3 of Sugar Free Lactose Permease at Acidic pH within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Hg503

b:53.8
occ:0.44
O A:CYS355 2.2 35.1 1.0
SG A:CYS355 2.8 23.7 1.0
C A:CYS355 2.9 38.1 1.0
CB A:CYS355 3.3 35.2 1.0
O A:LEU57 3.5 55.0 1.0
N A:PHE356 3.6 40.1 1.0
CA A:CYS355 3.7 38.4 1.0
CA A:PHE356 3.8 43.3 1.0
CB A:PHE356 3.9 43.9 1.0
CG A:PRO61 3.9 41.6 1.0
CD A:PRO61 4.0 44.3 1.0
CB A:PRO61 4.0 42.5 1.0
CD1 A:PHE356 4.1 49.5 1.0
C A:LEU57 4.3 56.6 1.0
CG A:LEU57 4.3 69.6 1.0
CG A:LEU351 4.4 42.7 1.0
CA A:LEU57 4.4 59.8 1.0
CD2 A:LEU351 4.5 43.4 1.0
CG A:PHE356 4.5 48.0 1.0
CB A:LEU57 4.8 63.4 1.0
CD2 A:LEU57 4.9 76.5 1.0
N A:CYS355 4.9 44.5 1.0
N A:PRO61 5.0 43.1 1.0

Mercury binding site 4 out of 5 in 2cfp

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Mercury binding site 4 out of 5 in the Sugar Free Lactose Permease at Acidic pH


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 4 of Sugar Free Lactose Permease at Acidic pH within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Hg504

b:67.7
occ:0.25
CA A:LEU330 3.7 36.7 1.0
O A:LEU329 4.0 31.8 1.0
SG A:CYS333 4.1 41.3 1.0
CB A:LEU330 4.1 33.7 1.0
CB A:CYS333 4.2 34.1 1.0
N A:LEU330 4.2 34.6 1.0
C A:LEU329 4.3 33.3 1.0
CE2 A:PHE354 4.3 65.9 1.0
CG A:LEU329 4.5 36.2 1.0
CG A:LEU330 4.6 32.9 1.0
CD2 A:LEU329 4.7 39.1 1.0
O A:LEU330 4.7 39.0 1.0
C A:LEU330 4.8 39.4 1.0

Mercury binding site 5 out of 5 in 2cfp

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Mercury binding site 5 out of 5 in the Sugar Free Lactose Permease at Acidic pH


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 5 of Sugar Free Lactose Permease at Acidic pH within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Hg505

b:51.6
occ:0.45
SG A:CYS234 2.3 4.8 1.0
SD A:MET365 2.4 42.3 1.0
CE A:MET365 2.7 42.8 1.0
O A:ILE230 2.7 49.5 1.0
CB A:CYS234 3.0 13.6 1.0
OG1 A:THR235 3.0 26.6 1.0
N A:THR235 3.2 20.9 1.0
O A:GLY231 3.6 42.4 1.0
C A:CYS234 3.8 17.9 1.0
CA A:THR235 3.8 27.1 1.0
CA A:CYS234 3.9 18.6 1.0
C A:ILE230 3.9 49.4 1.0
CG A:MET365 3.9 37.1 1.0
CB A:THR235 3.9 25.0 1.0
CA A:GLY231 4.3 50.8 1.0
C A:GLY231 4.3 48.2 1.0
N A:CYS234 4.4 24.9 1.0
CB A:ALA361 4.5 24.5 1.0
CB A:MET365 4.5 30.7 1.0
N A:GLY231 4.6 52.8 1.0
O A:CYS234 4.7 14.5 1.0

Reference:

O.Mirza, L.Guan, G.Verner, S.Iwata, H.R.Kaback. Structural Evidence For Induced Fit and A Mechanism For Sugar/H(+) Symport in Lacy. Embo J. V. 25 2038 2006.
ISSN: ISSN 0261-4189
PubMed: 16525509
DOI: 10.1038/SJ.EMBOJ.7601028
Page generated: Sun Dec 13 19:06:29 2020

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