Atomistry » Mercury » PDB 2esw-2o1f » 2fmz
Atomistry »
  Mercury »
    PDB 2esw-2o1f »
      2fmz »

Mercury in PDB 2fmz: Carbonic Anhydrase Activators. Activation of Isoforms I, II, IV, Va, VII and Xiv with L- and D- Phenylalanine, Structure with D- Phenylalanine.

Enzymatic activity of Carbonic Anhydrase Activators. Activation of Isoforms I, II, IV, Va, VII and Xiv with L- and D- Phenylalanine, Structure with D- Phenylalanine.

All present enzymatic activity of Carbonic Anhydrase Activators. Activation of Isoforms I, II, IV, Va, VII and Xiv with L- and D- Phenylalanine, Structure with D- Phenylalanine.:
4.2.1.1;

Protein crystallography data

The structure of Carbonic Anhydrase Activators. Activation of Isoforms I, II, IV, Va, VII and Xiv with L- and D- Phenylalanine, Structure with D- Phenylalanine., PDB code: 2fmz was solved by C.Temperini, A.Scozzafava, D.Vullo, C.T.Supuran, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 14.35 / 1.60
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 42.090, 41.380, 72.100, 90.00, 104.40, 90.00
R / Rfree (%) 21.8 / 23.7

Other elements in 2fmz:

The structure of Carbonic Anhydrase Activators. Activation of Isoforms I, II, IV, Va, VII and Xiv with L- and D- Phenylalanine, Structure with D- Phenylalanine. also contains other interesting chemical elements:

Zinc (Zn) 1 atom

Mercury Binding Sites:

The binding sites of Mercury atom in the Carbonic Anhydrase Activators. Activation of Isoforms I, II, IV, Va, VII and Xiv with L- and D- Phenylalanine, Structure with D- Phenylalanine. (pdb code 2fmz). This binding sites where shown within 5.0 Angstroms radius around Mercury atom.
In total only one binding site of Mercury was determined in the Carbonic Anhydrase Activators. Activation of Isoforms I, II, IV, Va, VII and Xiv with L- and D- Phenylalanine, Structure with D- Phenylalanine., PDB code: 2fmz:

Mercury binding site 1 out of 1 in 2fmz

Go back to Mercury Binding Sites List in 2fmz
Mercury binding site 1 out of 1 in the Carbonic Anhydrase Activators. Activation of Isoforms I, II, IV, Va, VII and Xiv with L- and D- Phenylalanine, Structure with D- Phenylalanine.


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 1 of Carbonic Anhydrase Activators. Activation of Isoforms I, II, IV, Va, VII and Xiv with L- and D- Phenylalanine, Structure with D- Phenylalanine. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Hg263

b:19.6
occ:1.00
SG A:CYS206 2.4 11.4 1.0
O A:HOH451 2.4 18.1 1.0
O A:HOH340 2.7 16.6 1.0
O A:GLN137 2.9 5.9 1.0
O A:GLU205 3.0 6.8 1.0
CB A:CYS206 3.1 5.8 1.0
C A:GLN137 3.3 7.5 1.0
C A:GLU205 3.4 5.2 1.0
O A:HOH378 3.5 32.0 1.0
CA A:CYS206 3.5 5.1 1.0
N A:CYS206 3.6 5.9 1.0
N A:GLN137 3.6 8.6 1.0
O A:HOH333 3.8 27.4 1.0
O A:VAL135 3.8 14.0 1.0
N A:PRO138 3.8 7.5 1.0
C A:GLN136 3.9 11.0 1.0
CA A:GLN137 4.0 6.8 1.0
CA A:PRO138 4.1 7.9 1.0
C A:VAL135 4.2 11.7 1.0
N A:GLU205 4.3 6.0 1.0
O A:GLN136 4.3 12.8 1.0
CA A:GLN136 4.3 12.9 1.0
CA A:GLU205 4.4 5.6 1.0
N A:GLN136 4.5 10.9 1.0
O A:HOH344 4.8 34.5 1.0
CD A:PRO138 4.8 10.9 1.0
C A:CYS206 4.9 5.9 1.0
C A:LEU204 4.9 5.9 1.0
CB A:LEU204 5.0 9.7 1.0
C A:PRO138 5.0 7.7 1.0

Reference:

C.Temperini, A.Scozzafava, D.Vullo, C.T.Supuran. Carbonic Anhydrase Activators. Activation of Isoforms I, II, IV, Va, VII, and Xiv with L- and D-Phenylalanine and Crystallographic Analysis of Their Adducts with Isozyme II: Stereospecific Recognition Within the Active Site of An Enzyme and Its Consequences For the Drug Design. J.Med.Chem. V. 49 3019 2006.
ISSN: ISSN 0022-2623
PubMed: 16686544
DOI: 10.1021/JM0603320
Page generated: Sun Dec 13 19:06:48 2020

Last articles

Zn in 7VD8
Zn in 7V1R
Zn in 7V1Q
Zn in 7VPF
Zn in 7T85
Zn in 7T5F
Zn in 7NF9
Zn in 7M4M
Zn in 7M4O
Zn in 7M4N
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy