Mercury in PDB 2o1f: Natural Occuring Mutation of Human Abo(H) Galactosyltransferase: Gtb/M214R

The structure of Natural Occuring Mutation of Human Abo(H) Galactosyltransferase: Gtb/M214R, PDB code: 2o1f was solved by J.A.Letts, S.N.Borisova, S.V.Evans, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	20.00 / 1.99
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	52.520, 149.670, 79.740, 90.00, 90.00, 90.00
R / Rfree (%)	18.4 / 23.6

The binding sites of Mercury atom in the Natural Occuring Mutation of Human Abo(H) Galactosyltransferase: Gtb/M214R (pdb code 2o1f). This binding sites where shown within 5.0 Angstroms radius around Mercury atom.
In total 3 binding sites of Mercury where determined in the Natural Occuring Mutation of Human Abo(H) Galactosyltransferase: Gtb/M214R, PDB code: 2o1f:
Jump to Mercury binding site number: 1; 2; 3;

Mercury binding site 1 out of 3 in the Natural Occuring Mutation of Human Abo(H) Galactosyltransferase: Gtb/M214R


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 1 of Natural Occuring Mutation of Human Abo(H) Galactosyltransferase: Gtb/M214R within 5.0Å range: probe atom residue distance (Å) B Occ A:Hg401 b:44.0 occ:0.50 SG A:CYS284 2.5 26.0 0.5 OD1 A:ASP302 2.9 42.0 1.0 SD A:MET288 3.1 39.5 1.0 O A:CYS284 3.5 29.7 0.5 CB A:CYS284 3.5 26.8 0.5 C A:CYS284 3.5 29.8 0.5 N A:HIS285 3.7 29.9 1.0 C A:CYS284 3.8 28.9 0.5 CG A:ASP302 3.9 38.7 1.0 CB A:CYS284 3.9 29.0 0.5 CA A:HIS285 4.0 32.4 1.0 CG A:MET288 4.0 35.9 1.0 O A:CYS284 4.1 28.9 0.5 CA A:CYS284 4.3 27.7 0.5 CA A:CYS284 4.3 29.2 0.5 CB A:ASP302 4.5 32.9 1.0 CB A:MET288 4.6 33.6 1.0 CB A:HIS285 4.6 33.4 1.0 OD2 A:ASP302 4.7 43.6 1.0 CE A:MET288 4.8 43.4 1.0 HG A:HG402 4.8 43.7 0.5 O A:THR281 4.9 28.0 1.0 CA A:ASP302 5.0 31.3 1.0

Mercury binding site 2 out of 3 in the Natural Occuring Mutation of Human Abo(H) Galactosyltransferase: Gtb/M214R


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 2 of Natural Occuring Mutation of Human Abo(H) Galactosyltransferase: Gtb/M214R within 5.0Å range: probe atom residue distance (Å) B Occ A:Hg402 b:43.7 occ:0.50 SG A:CYS284 2.7 32.0 0.5 CB A:CYS284 2.9 29.0 0.5 SG A:CYS284 3.0 26.0 0.5 CB A:CYS284 3.1 26.8 0.5 CD2 A:LEU280 3.6 24.2 1.0 O A:ASP302 3.8 27.5 1.0 CA A:LEU306 4.0 22.1 1.0 N A:LEU306 4.0 22.4 1.0 CB A:LEU306 4.1 21.3 1.0 CA A:CYS284 4.4 27.7 0.5 CD1 A:LEU306 4.5 23.5 1.0 CA A:CYS284 4.5 29.2 0.5 CG A:LEU280 4.5 24.2 1.0 O A:LEU280 4.6 24.9 1.0 C A:HIS305 4.6 23.8 1.0 C A:ASP302 4.7 28.9 1.0 CB A:ASP302 4.7 32.9 1.0 CB A:HIS305 4.8 24.8 1.0 HG A:HG401 4.8 44.0 0.5 CG A:LEU306 5.0 20.8 1.0 CA A:ASP302 5.0 31.3 1.0

Mercury binding site 3 out of 3 in the Natural Occuring Mutation of Human Abo(H) Galactosyltransferase: Gtb/M214R


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 3 of Natural Occuring Mutation of Human Abo(H) Galactosyltransferase: Gtb/M214R within 5.0Å range: probe atom residue distance (Å) B Occ A:Hg403 b:30.6 occ:0.70 O A:HOH524 1.3 14.8 1.0 SG A:CYS209 2.4 28.4 1.0 OG1 A:THR119 2.9 28.1 1.0 CB A:CYS209 3.2 23.1 1.0 CB A:THR119 3.9 25.6 1.0 CG2 A:THR119 3.9 24.8 1.0 O A:HOH422 4.0 30.1 1.0 CG1 A:VAL277 4.1 19.8 1.0 CA A:CYS209 4.1 23.1 1.0 CD1 A:LEU207 4.6 25.3 1.0 N A:CYS209 4.8 21.5 1.0 CD2 A:LEU207 4.9 27.1 1.0 CZ A:PHE270 4.9 23.4 1.0 CB A:LEU207 5.0 23.6 1.0

M.Persson, J.A.Letts, B.Hosseini-Maaf, S.N.Borisova, M.M.Palcic, S.V.Evans, M.L.Olsson. Structural Effects of Naturally Occurring Human Blood Group B Galactosyltransferase Mutations Adjacent to the Dxd Motif. J.Biol.Chem. V. 282 9564 2007.
ISSN: ISSN 0021-9258
PubMed: 17259183
DOI: 10.1074/JBC.M610998200