Atomistry » Mercury » PDB 2o1g-3b4f » 2q1b
Atomistry »
  Mercury »
    PDB 2o1g-3b4f »
      2q1b »

Mercury in PDB 2q1b: Carbonic Anhydrase II in Complex with Saccharin

Enzymatic activity of Carbonic Anhydrase II in Complex with Saccharin

All present enzymatic activity of Carbonic Anhydrase II in Complex with Saccharin:
4.2.1.1;

Protein crystallography data

The structure of Carbonic Anhydrase II in Complex with Saccharin, PDB code: 2q1b was solved by G.Klebe, A.Heine, K.Koehler, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 10.00 / 1.70
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 42.220, 41.610, 72.160, 90.00, 104.44, 90.00
R / Rfree (%) 14.7 / 21.8

Other elements in 2q1b:

The structure of Carbonic Anhydrase II in Complex with Saccharin also contains other interesting chemical elements:

Zinc (Zn) 2 atoms

Mercury Binding Sites:

The binding sites of Mercury atom in the Carbonic Anhydrase II in Complex with Saccharin (pdb code 2q1b). This binding sites where shown within 5.0 Angstroms radius around Mercury atom.
In total only one binding site of Mercury was determined in the Carbonic Anhydrase II in Complex with Saccharin, PDB code: 2q1b:

Mercury binding site 1 out of 1 in 2q1b

Go back to Mercury Binding Sites List in 2q1b
Mercury binding site 1 out of 1 in the Carbonic Anhydrase II in Complex with Saccharin


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 1 of Carbonic Anhydrase II in Complex with Saccharin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Hg450

b:28.6
occ:1.00
SG A:CYS206 1.9 22.8 1.0
C4 A:BEZ455 2.4 24.0 1.0
O A:GLN137 2.9 15.0 1.0
C3 A:BEZ455 3.1 11.1 1.0
CB A:CYS206 3.1 20.8 1.0
O A:GLU205 3.2 16.6 1.0
C A:GLN137 3.4 15.4 1.0
C A:GLU205 3.5 15.8 1.0
CA A:CYS206 3.5 15.1 1.0
C5 A:BEZ455 3.6 31.9 1.0
N A:GLN137 3.7 24.1 1.0
N A:CYS206 3.7 13.0 1.0
O A:VAL135 3.8 20.0 1.0
C A:GLN136 4.0 19.4 1.0
N A:PRO138 4.0 16.6 1.0
O A:HOH592 4.1 23.3 1.0
CA A:GLN137 4.1 17.5 1.0
CA A:PRO138 4.2 13.8 1.0
C A:VAL135 4.2 21.5 1.0
N A:GLU205 4.3 13.2 1.0
CA A:GLN136 4.4 13.6 1.0
CA A:GLU205 4.4 11.2 1.0
C2 A:BEZ455 4.5 33.0 1.0
O A:GLN136 4.5 17.2 1.0
N A:GLN136 4.6 15.7 1.0
C6 A:BEZ455 4.8 30.6 1.0
CB A:LEU204 4.8 15.4 1.0
C A:LEU204 4.8 16.3 1.0
CA A:VAL135 4.9 21.9 1.0
C A:CYS206 5.0 17.5 1.0

Reference:

K.Kohler, A.Hillebrecht, J.Schulze Wischeler, A.Innocenti, A.Heine, C.T.Supuran, G.Klebe. Saccharin Inhibits Carbonic Anhydrases: Possible Explanation For Its Unpleasant Metallic Aftertaste. Angew.Chem.Int.Ed.Engl. V. 46 7697 2007.
ISSN: ISSN 1433-7851
PubMed: 17705204
DOI: 10.1002/ANIE.200701189
Page generated: Sun Dec 13 19:08:02 2020

Last articles

Zn in 8WB0
Zn in 8WAX
Zn in 8WAU
Zn in 8WAZ
Zn in 8WAY
Zn in 8WAV
Zn in 8WAW
Zn in 8WAT
Zn in 8W7M
Zn in 8WD3
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy