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Mercury in PDB 4lsg: Structure of Mouse P-Glycoprotein

Enzymatic activity of Structure of Mouse P-Glycoprotein

All present enzymatic activity of Structure of Mouse P-Glycoprotein:
3.6.3.44;

Protein crystallography data

The structure of Structure of Mouse P-Glycoprotein, PDB code: 4lsg was solved by G.Chang, P.Szewczyk, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 19.98 / 3.80
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 97.542, 115.426, 378.858, 90.00, 90.00, 90.00
R / Rfree (%) 33.6 / 35.7

Mercury Binding Sites:

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 12;

Binding sites:

The binding sites of Mercury atom in the Structure of Mouse P-Glycoprotein (pdb code 4lsg). This binding sites where shown within 5.0 Angstroms radius around Mercury atom.
In total 12 binding sites of Mercury where determined in the Structure of Mouse P-Glycoprotein, PDB code: 4lsg:
Jump to Mercury binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Mercury binding site 1 out of 12 in 4lsg

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Mercury binding site 1 out of 12 in the Structure of Mouse P-Glycoprotein


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 1 of Structure of Mouse P-Glycoprotein within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Hg1301

b:1.0
occ:1.00
CE3 A:TRP132 2.3 0.2 1.0
SG A:CYS133 2.4 0.0 1.0
CD2 A:TRP132 2.5 0.0 1.0
CZ3 A:TRP132 3.0 0.9 1.0
CD2 A:PHE934 3.0 0.2 1.0
CG A:TRP132 3.1 93.8 1.0
CE2 A:TRP132 3.3 80.6 1.0
CE2 A:PHE934 3.4 0.2 1.0
CB A:TRP132 3.6 96.5 1.0
CH2 A:TRP132 3.7 98.3 1.0
CZ2 A:TRP132 3.8 85.2 1.0
N A:CYS133 3.9 88.2 1.0
CB A:CYS133 3.9 0.6 1.0
CD1 A:TRP132 4.0 71.2 1.0
CG A:PHE934 4.0 98.5 1.0
CA A:CYS133 4.1 0.3 1.0
NE1 A:TRP132 4.1 55.4 1.0
CB A:PHE934 4.5 87.3 1.0
C A:TRP132 4.5 93.6 1.0
CZ A:PHE934 4.6 0.1 1.0
OD2 A:ASP184 4.6 93.3 1.0
CA A:TRP132 4.7 96.8 1.0

Mercury binding site 2 out of 12 in 4lsg

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Mercury binding site 2 out of 12 in the Structure of Mouse P-Glycoprotein


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 2 of Structure of Mouse P-Glycoprotein within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Hg1302

b:0.3
occ:0.17
SG A:CYS427 2.4 0.0 1.0
CB A:CYS427 3.6 0.8 1.0
CE2 A:TYR397 4.6 90.8 1.0
CD2 A:TYR397 4.6 88.3 1.0
CG1 A:ILE405 4.8 89.8 1.0
CA A:CYS427 5.0 0.2 1.0

Mercury binding site 3 out of 12 in 4lsg

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Mercury binding site 3 out of 12 in the Structure of Mouse P-Glycoprotein


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 3 of Structure of Mouse P-Glycoprotein within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Hg1303

b:1.0
occ:1.00
SG A:CYS713 2.4 60.2 1.0
C A:CYS713 2.7 90.5 1.0
CB A:CYS713 2.7 84.7 1.0
OG1 A:THR765 2.8 0.6 1.0
O A:CYS713 2.9 94.8 1.0
N A:ALA714 3.0 94.5 1.0
CD A:GLN769 3.1 69.7 1.0
CB A:GLN769 3.1 83.4 1.0
OE1 A:GLN769 3.2 72.4 1.0
CA A:CYS713 3.2 95.2 1.0
NE2 A:GLN769 3.5 65.6 1.0
CG A:GLN769 3.5 81.8 1.0
CA A:ALA714 3.6 0.9 1.0
O A:THR765 3.8 89.4 1.0
O A:GLY710 3.9 0.1 1.0
CB A:THR765 4.2 95.4 1.0
CA A:GLN769 4.2 88.7 1.0
N A:CYS713 4.3 97.0 1.0
CB A:ALA714 4.4 0.5 1.0
C A:THR765 4.4 86.6 1.0
N A:GLN769 4.5 89.1 1.0
CA A:THR765 4.6 86.5 1.0
CB A:ASN717 4.7 96.7 1.0
C A:ALA714 4.8 95.0 1.0

Mercury binding site 4 out of 12 in 4lsg

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Mercury binding site 4 out of 12 in the Structure of Mouse P-Glycoprotein


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 4 of Structure of Mouse P-Glycoprotein within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Hg1304

b:1.0
occ:1.00
SG A:CYS1070 2.4 80.0 1.0
CE2 A:TYR1040 2.7 85.2 1.0
CB A:CYS1070 2.8 0.7 1.0
CZ A:TYR1040 3.2 93.9 1.0
OH A:TYR1040 3.3 90.6 1.0
CD2 A:TYR1040 3.5 91.0 1.0
CA A:CYS1070 4.3 0.9 1.0
CE1 A:TYR1040 4.4 96.9 1.0
CG A:TYR1040 4.6 0.6 1.0
CG2 A:THR1074 4.8 82.5 1.0
CD1 A:TYR1040 4.9 0.7 1.0

Mercury binding site 5 out of 12 in 4lsg

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Mercury binding site 5 out of 12 in the Structure of Mouse P-Glycoprotein


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 5 of Structure of Mouse P-Glycoprotein within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Hg1305

b:1.0
occ:1.00
O A:ASP1120 2.2 77.1 1.0
SG A:CYS1121 2.4 41.0 1.0
C A:ASP1120 2.7 92.9 1.0
N A:ASP1120 3.0 0.5 1.0
CB A:CYS1121 3.0 82.4 1.0
NH1 A:ARG272 3.1 96.3 1.0
CB A:PHE1119 3.1 0.5 1.0
OD1 A:ASP1120 3.2 0.3 1.0
C A:PHE1119 3.3 0.0 1.0
NH2 A:ARG272 3.3 92.0 1.0
CA A:ASP1120 3.5 0.5 1.0
N A:CYS1121 3.5 96.2 1.0
CZ A:ARG272 3.6 94.1 1.0
CA A:PHE1119 3.7 0.1 1.0
CA A:CYS1121 3.7 92.2 1.0
O A:PHE1119 3.8 0.4 1.0
CG A:ASP1120 4.0 0.2 1.0
CG A:PHE1119 4.3 0.9 1.0
CB A:ASP1120 4.3 0.2 1.0
ND2 A:ASN1126 4.7 0.9 1.0
CD2 A:PHE1119 4.8 0.8 1.0
NE A:ARG272 4.9 90.8 1.0
OD2 A:ASP1120 4.9 0.4 1.0
OE1 A:GLU252 5.0 86.0 1.0
N A:PHE1119 5.0 0.6 1.0

Mercury binding site 6 out of 12 in 4lsg

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Mercury binding site 6 out of 12 in the Structure of Mouse P-Glycoprotein


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 6 of Structure of Mouse P-Glycoprotein within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Hg1306

b:1.0
occ:1.00
SG A:CYS1223 2.4 97.7 1.0
NH1 A:ARG1218 2.6 49.3 1.0
CD A:ARG1218 2.6 84.2 1.0
NE A:ARG1218 3.0 78.9 1.0
CZ A:ARG1218 3.0 67.2 1.0
CB A:CYS1223 3.2 82.0 1.0
OG1 A:THR1061 3.4 0.6 1.0
CG A:ARG1218 3.7 92.7 1.0
CG1 A:VAL1225 4.0 63.5 1.0
CG2 A:THR1061 4.0 90.1 1.0
NH2 A:ARG1218 4.1 74.4 1.0
CB A:ARG1218 4.1 96.7 1.0
CB A:THR1061 4.2 98.5 1.0
CB A:VAL1225 4.3 75.6 1.0
CA A:CYS1223 4.5 79.6 1.0
CD2 A:LEU1195 4.5 79.2 1.0
C A:CYS1223 4.5 74.3 1.0
CA A:THR1061 4.7 88.2 1.0
N A:ILE1224 4.8 68.4 1.0
O A:CYS1223 4.8 79.7 1.0
N A:VAL1225 4.8 78.5 1.0

Mercury binding site 7 out of 12 in 4lsg

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Mercury binding site 7 out of 12 in the Structure of Mouse P-Glycoprotein


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 7 of Structure of Mouse P-Glycoprotein within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Hg1301

b:1.0
occ:1.00
CE3 B:TRP132 2.4 90.4 1.0
SG B:CYS133 2.4 0.7 1.0
CD2 B:TRP132 2.5 89.2 1.0
CZ3 B:TRP132 3.0 96.0 1.0
CD2 B:PHE934 3.1 0.2 1.0
CG B:TRP132 3.1 86.2 1.0
CE2 B:TRP132 3.3 78.7 1.0
CE2 B:PHE934 3.3 0.2 1.0
CH2 B:TRP132 3.6 91.2 1.0
CB B:TRP132 3.7 92.2 1.0
CZ2 B:TRP132 3.8 79.8 1.0
N B:CYS133 3.8 84.9 1.0
CB B:CYS133 3.9 94.7 1.0
CD1 B:TRP132 3.9 65.2 1.0
CA B:CYS133 4.0 85.5 1.0
NE1 B:TRP132 4.0 50.9 1.0
CG B:PHE934 4.1 0.5 1.0
C B:TRP132 4.5 95.0 1.0
CZ B:PHE934 4.5 0.5 1.0
CB B:PHE934 4.7 89.1 1.0
CA B:TRP132 4.8 96.6 1.0
OD2 B:ASP184 4.8 98.3 1.0

Mercury binding site 8 out of 12 in 4lsg

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Mercury binding site 8 out of 12 in the Structure of Mouse P-Glycoprotein


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 8 of Structure of Mouse P-Glycoprotein within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Hg1302

b:0.3
occ:0.13
SG B:CYS427 2.4 0.6 1.0
CB B:CYS427 3.7 0.5 1.0
CA B:CYS427 4.5 0.7 1.0
N B:CYS427 4.8 0.1 1.0

Mercury binding site 9 out of 12 in 4lsg

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Mercury binding site 9 out of 12 in the Structure of Mouse P-Glycoprotein


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 9 of Structure of Mouse P-Glycoprotein within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Hg1303

b:1.0
occ:1.00
SG B:CYS713 2.4 57.1 1.0
CB B:CYS713 2.7 94.5 1.0
C B:CYS713 2.8 98.3 1.0
CB B:GLN769 2.9 98.9 1.0
OG1 B:THR765 3.0 0.1 1.0
O B:CYS713 3.1 0.3 1.0
CD B:GLN769 3.1 94.9 1.0
N B:ALA714 3.1 0.1 1.0
OE1 B:GLN769 3.2 95.8 1.0
CA B:CYS713 3.3 0.5 1.0
CG B:GLN769 3.4 99.9 1.0
NE2 B:GLN769 3.6 90.3 1.0
CA B:ALA714 3.7 0.2 1.0
O B:THR765 3.7 0.9 1.0
O B:GLY710 3.8 0.2 1.0
CA B:GLN769 4.0 0.1 1.0
N B:GLN769 4.3 0.0 1.0
CB B:THR765 4.3 0.9 1.0
N B:CYS713 4.4 0.1 1.0
CB B:ALA714 4.4 0.5 1.0
C B:THR765 4.5 0.4 1.0
CA B:THR765 4.7 96.2 1.0
C B:GLY710 4.9 0.1 1.0
CB B:ASN717 4.9 0.9 1.0
C B:ALA714 4.9 0.6 1.0

Mercury binding site 10 out of 12 in 4lsg

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Mercury binding site 10 out of 12 in the Structure of Mouse P-Glycoprotein


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 10 of Structure of Mouse P-Glycoprotein within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Hg1304

b:1.0
occ:1.00
SG B:CYS1070 2.4 95.9 1.0
CE2 B:TYR1040 2.7 0.4 1.0
CB B:CYS1070 2.8 0.4 1.0
CZ B:TYR1040 3.3 91.5 1.0
OH B:TYR1040 3.4 82.8 1.0
CD2 B:TYR1040 3.5 0.5 1.0
CA B:CYS1070 4.3 0.7 1.0
CE1 B:TYR1040 4.4 91.2 1.0
CG B:TYR1040 4.6 0.1 1.0
CG2 B:THR1074 4.7 98.3 1.0
CD1 B:TYR1040 5.0 0.7 1.0

Reference:

G.Chang, P.Szewczyk. N/A N/A.
Page generated: Sun Dec 13 19:11:22 2020

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