Atomistry » Mercury » PDB 4ihd-4q7w » 4q7s
Atomistry »
  Mercury »
    PDB 4ihd-4q7w »
      4q7s »

Mercury in PDB 4q7s: Crystal Structure of 1-Hydroxy-4-Methylpyridine-2(1H)-Thione Bound to Human Carbonic Anhydrase II

Enzymatic activity of Crystal Structure of 1-Hydroxy-4-Methylpyridine-2(1H)-Thione Bound to Human Carbonic Anhydrase II

All present enzymatic activity of Crystal Structure of 1-Hydroxy-4-Methylpyridine-2(1H)-Thione Bound to Human Carbonic Anhydrase II:
4.2.1.1;

Protein crystallography data

The structure of Crystal Structure of 1-Hydroxy-4-Methylpyridine-2(1H)-Thione Bound to Human Carbonic Anhydrase II, PDB code: 4q7s was solved by D.P.Martin, S.M.Cohen, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 40.84 / 1.80
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 42.113, 41.418, 71.987, 90.00, 104.12, 90.00
R / Rfree (%) 18.9 / 22.6

Other elements in 4q7s:

The structure of Crystal Structure of 1-Hydroxy-4-Methylpyridine-2(1H)-Thione Bound to Human Carbonic Anhydrase II also contains other interesting chemical elements:

Zinc (Zn) 1 atom

Mercury Binding Sites:

The binding sites of Mercury atom in the Crystal Structure of 1-Hydroxy-4-Methylpyridine-2(1H)-Thione Bound to Human Carbonic Anhydrase II (pdb code 4q7s). This binding sites where shown within 5.0 Angstroms radius around Mercury atom.
In total only one binding site of Mercury was determined in the Crystal Structure of 1-Hydroxy-4-Methylpyridine-2(1H)-Thione Bound to Human Carbonic Anhydrase II, PDB code: 4q7s:

Mercury binding site 1 out of 1 in 4q7s

Go back to Mercury Binding Sites List in 4q7s
Mercury binding site 1 out of 1 in the Crystal Structure of 1-Hydroxy-4-Methylpyridine-2(1H)-Thione Bound to Human Carbonic Anhydrase II


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 1 of Crystal Structure of 1-Hydroxy-4-Methylpyridine-2(1H)-Thione Bound to Human Carbonic Anhydrase II within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Hg303

b:13.0
occ:0.70
 HG A:MBO303 0.0 13.0 0.7
SG A:CYS206 2.1 19.4 1.0
CE1 A:MBO303 2.2 15.8 0.7
O A:GLN137 2.9 8.0 1.0
CE2 A:MBO303 2.9 14.0 0.7
O A:VAL135 3.2 9.2 1.0
CE6 A:MBO303 3.2 7.4 0.7
CB A:CYS206 3.3 14.1 1.0
CA A:CYS206 3.5 12.1 1.0
C A:GLN137 3.5 9.0 1.0
O A:GLU205 3.6 9.6 1.0
C A:GLU205 3.6 11.3 1.0
N A:CYS206 3.6 11.5 1.0
N A:GLN137 3.7 10.0 1.0
C A:VAL135 3.7 9.5 1.0
C A:GLN136 4.1 11.7 1.0
N A:GLU205 4.1 8.2 1.0
CA A:GLN137 4.2 9.2 1.0
CE3 A:MBO303 4.2 18.6 0.7
CB A:LEU204 4.3 10.3 1.0
N A:PRO138 4.3 9.7 1.0
CA A:GLN136 4.3 11.2 1.0
N A:GLN136 4.3 10.0 1.0
CA A:GLU205 4.4 9.4 1.0
CA A:VAL135 4.5 9.7 1.0
CE5 A:MBO303 4.5 15.8 0.7
CA A:PRO138 4.5 8.8 1.0
C A:LEU204 4.5 9.2 1.0
O A:GLN136 4.7 10.9 1.0
O A:ALA134 4.8 7.4 1.0
CE4 A:MBO303 4.8 15.8 0.7
CA A:LEU204 5.0 9.6 1.0
C A:CYS206 5.0 9.6 1.0

Reference:

D.P.Martin, P.G.Blachly, J.A.Mccammon, S.M.Cohen. Exploring the Influence of the Protein Environment on Metal-Binding Pharmacophores. J.Med.Chem. V. 57 7126 2014.
ISSN: ISSN 0022-2623
PubMed: 25116076
DOI: 10.1021/JM500984B
Page generated: Sun Aug 11 05:13:22 2024

Last articles

Zn in 9JPJ
Zn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy