Mercury in PDB 5eoi: Crystal Structure of Copper Bound Human Carbonic Anhydrase II

All present enzymatic activity of Crystal Structure of Copper Bound Human Carbonic Anhydrase II:
4.2.1.1;

The structure of Crystal Structure of Copper Bound Human Carbonic Anhydrase II, PDB code: 5eoi was solved by M.Ferraroni, A.Scozzafava, C.T.Supuran, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	14.75 / 1.80
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	42.026, 41.479, 72.067, 90.00, 104.61, 90.00
R / Rfree (%)	14.7 / 20.6

The structure of Crystal Structure of Copper Bound Human Carbonic Anhydrase II also contains other interesting chemical elements:

Zinc	(Zn)	1 atom
Chlorine	(Cl)	1 atom
Copper	(Cu)	1 atom

The binding sites of Mercury atom in the Crystal Structure of Copper Bound Human Carbonic Anhydrase II (pdb code 5eoi). This binding sites where shown within 5.0 Angstroms radius around Mercury atom.
In total only one binding site of Mercury was determined in the Crystal Structure of Copper Bound Human Carbonic Anhydrase II, PDB code: 5eoi:

Mercury binding site 1 out of 1 in the Crystal Structure of Copper Bound Human Carbonic Anhydrase II


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 1 of Crystal Structure of Copper Bound Human Carbonic Anhydrase II within 5.0Å range: probe atom residue distance (Å) B Occ A:Hg302 b:13.3 occ:0.85 CL A:CL305 2.2 22.9 1.0 SG A:CYS206 2.2 19.5 1.0 O A:GLN137 2.8 13.0 1.0 O A:HOH603 3.0 29.2 1.0 O A:GLU205 3.2 12.5 1.0 CB A:CYS206 3.2 13.4 1.0 C A:GLN137 3.4 12.6 1.0 O A:VAL135 3.4 15.4 1.0 CA A:CYS206 3.5 12.4 1.0 N A:GLN137 3.6 14.6 1.0 C A:GLU205 3.6 13.3 1.0 N A:CYS206 3.8 12.2 1.0 C A:VAL135 3.9 15.4 1.0 C A:GLN136 3.9 16.1 1.0 N A:PRO138 4.0 12.8 1.0 CA A:GLN137 4.0 13.4 1.0 CA A:PRO138 4.1 12.4 0.5 CA A:PRO138 4.2 12.4 0.5 O A:HOH600 4.2 22.2 1.0 O A:HOH525 4.4 19.1 1.0 N A:GLN136 4.4 16.4 1.0 CA A:GLN136 4.4 17.3 1.0 N A:GLU205 4.5 11.9 1.0 O A:GLN136 4.5 14.8 1.0 CA A:VAL135 4.6 15.3 1.0 CA A:GLU205 4.6 12.2 1.0 O A:ALA134 4.8 11.7 1.0 O A:HOH730 4.9 31.7 1.0 CB A:LEU204 4.9 14.0 1.0 CD A:PRO138 5.0 13.2 0.5 C A:LEU204 5.0 12.2 1.0 C A:CYS206 5.0 11.3 1.0 O A:HOH509 5.0 34.7 1.0 C A:PRO138 5.0 12.1 1.0

M.Ferraroni, A.Scozzafava, C.T.Supuran, E.Rizzarelli, G.Tabbi. Crystal Structure of Copper Bound Human Carbonic Anhydrase II To Be Published.