Atomistry » Mercury » PDB 5lf8-6bvg » 5t71
Atomistry »
  Mercury »
    PDB 5lf8-6bvg »
      5t71 »

Mercury in PDB 5t71: Human Carboanhydrase F131C_C206S Double Mutant in Complex with Sa-2

Enzymatic activity of Human Carboanhydrase F131C_C206S Double Mutant in Complex with Sa-2

All present enzymatic activity of Human Carboanhydrase F131C_C206S Double Mutant in Complex with Sa-2:
4.2.1.1;

Protein crystallography data

The structure of Human Carboanhydrase F131C_C206S Double Mutant in Complex with Sa-2, PDB code: 5t71 was solved by K.H.Dubay, K.Iwan, L.Osorio-Planes, P.Geissler, M.Groll, D.Trauner, J.Broichhagen, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 15.00 / 1.30
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 42.350, 41.450, 72.460, 90.00, 104.29, 90.00
R / Rfree (%) 14.8 / 17.1

Other elements in 5t71:

The structure of Human Carboanhydrase F131C_C206S Double Mutant in Complex with Sa-2 also contains other interesting chemical elements:

Zinc (Zn) 1 atom

Mercury Binding Sites:

The binding sites of Mercury atom in the Human Carboanhydrase F131C_C206S Double Mutant in Complex with Sa-2 (pdb code 5t71). This binding sites where shown within 5.0 Angstroms radius around Mercury atom.
In total only one binding site of Mercury was determined in the Human Carboanhydrase F131C_C206S Double Mutant in Complex with Sa-2, PDB code: 5t71:

Mercury binding site 1 out of 1 in 5t71

Go back to Mercury Binding Sites List in 5t71
Mercury binding site 1 out of 1 in the Human Carboanhydrase F131C_C206S Double Mutant in Complex with Sa-2


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 1 of Human Carboanhydrase F131C_C206S Double Mutant in Complex with Sa-2 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Hg302

b:20.5
occ:1.00
HG A:HGB302 0.0 20.5 1.0
O A:HOH659 1.7 20.3 1.0
SG A:CYS130 2.2 15.1 1.0
C7 A:HGB302 2.3 23.6 1.0
O A:CYS130 3.1 10.5 1.0
C6 A:HGB302 3.2 24.9 1.0
C5 A:HGB302 3.2 23.7 1.0
CB A:CYS130 3.3 11.5 1.0
C A:CYS130 3.4 10.6 1.0
O A:HOH576 3.7 50.8 1.0
O A:HOH666 3.8 43.1 1.0
CA A:CYS130 3.9 11.4 1.0
N A:GLY131 4.0 12.4 1.0
O A:HOH657 4.0 36.7 1.0
CB A:VAL134 4.2 12.9 1.0
CA A:GLY131 4.4 12.7 1.0
C4 A:HGB302 4.5 26.5 1.0
CG1 A:VAL134 4.5 13.3 1.0
C3 A:HGB302 4.5 25.4 1.0
CD2 A:LEU140 4.6 12.5 1.0
CG2 A:VAL134 4.7 14.3 1.0

Reference:

K.H.Dubay, K.Iwan, L.Osorio-Planes, P.L.Geissler, M.Groll, D.Trauner, J.Broichhagen. A Predictive Approach For the Optical Control of Carbonic Anhydrase II Activity. Acs Chem. Biol. V. 13 793 2018.
ISSN: ESSN 1554-8937
PubMed: 29357237
DOI: 10.1021/ACSCHEMBIO.7B00862
Page generated: Sun Dec 13 19:13:08 2020

Last articles

Zn in 7VD8
Zn in 7V1R
Zn in 7V1Q
Zn in 7VPF
Zn in 7T85
Zn in 7T5F
Zn in 7NF9
Zn in 7M4M
Zn in 7M4O
Zn in 7M4N
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy