Mercury in PDB 6rh4: Human Carbonic Anhydrase II in Complex with 4-Nitrobenzenesulfonamide.

All present enzymatic activity of Human Carbonic Anhydrase II in Complex with 4-Nitrobenzenesulfonamide.:
4.2.1.1;

The structure of Human Carbonic Anhydrase II in Complex with 4-Nitrobenzenesulfonamide., PDB code: 6rh4 was solved by S.Gloeckner, A.Heine, G.Klebe, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	41.04 / 0.95
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	42.438, 41.522, 72.273, 90.00, 104.74, 90.00
R / Rfree (%)	10.3 / 11.7

The structure of Human Carbonic Anhydrase II in Complex with 4-Nitrobenzenesulfonamide. also contains other interesting chemical elements:

Zinc

(Zn)

1 atom

The binding sites of Mercury atom in the Human Carbonic Anhydrase II in Complex with 4-Nitrobenzenesulfonamide. (pdb code 6rh4). This binding sites where shown within 5.0 Angstroms radius around Mercury atom.
In total 2 binding sites of Mercury where determined in the Human Carbonic Anhydrase II in Complex with 4-Nitrobenzenesulfonamide., PDB code: 6rh4:
Jump to Mercury binding site number: 1; 2;

Mercury binding site 1 out of 2 in the Human Carbonic Anhydrase II in Complex with 4-Nitrobenzenesulfonamide.


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 1 of Human Carbonic Anhydrase II in Complex with 4-Nitrobenzenesulfonamide. within 5.0Å range: probe atom residue distance (Å) B Occ A:Hg302 b:11.7 occ:0.27 HG A:BE7303 1.3 7.1 0.7 SG A:CYS206 1.3 6.0 0.7 SG A:CYS206 2.3 9.6 0.3 O A:HOH546 2.5 16.3 1.0 HB3 A:CYS206 2.6 11.5 0.3 CB A:CYS206 2.8 5.4 0.7 CB A:CYS206 2.9 9.6 0.3 HB3 A:CYS206 3.0 6.5 0.7 O A:VAL135 3.1 9.5 1.0 O A:GLN137 3.3 6.6 1.0 HB3 A:LEU204 3.3 8.0 1.0 HA A:CYS206 3.4 5.8 0.7 C5 A:BE7303 3.4 7.2 0.7 HA A:CYS206 3.4 9.1 0.3 H A:GLN137 3.5 8.8 1.0 HB2 A:CYS206 3.5 6.5 0.7 CA A:CYS206 3.5 4.9 0.7 CA A:CYS206 3.5 7.6 0.3 C A:VAL135 3.5 8.1 1.0 HA A:VAL135 3.6 9.5 1.0 N A:CYS206 3.6 6.7 0.3 N A:GLN137 3.7 7.3 1.0 N A:CYS206 3.8 4.9 0.7 HB2 A:CYS206 3.8 11.5 0.3 C A:GLU205 3.8 5.5 1.0 O A:GLU205 3.8 6.8 1.0 O A:HOH569 3.8 11.9 1.0 HA A:GLN136 3.9 10.2 0.5 HA A:GLN136 3.9 9.9 0.6 C A:GLN137 3.9 6.4 1.0 H A:GLU205 4.0 6.4 1.0 H A:CYS206 4.0 8.1 0.3 C A:GLN136 4.1 7.7 0.6 C6 A:BE7303 4.1 8.4 0.7 CA A:VAL135 4.1 7.9 1.0 N A:GLN136 4.1 7.9 0.6 C A:GLN136 4.1 7.6 0.5 N A:GLN136 4.1 8.1 0.5 N A:GLU205 4.2 5.3 1.0 CA A:GLN136 4.2 8.2 0.6 CA A:GLN136 4.2 8.5 0.5 CB A:LEU204 4.2 6.7 1.0 HA A:PRO138 4.3 8.9 0.4 H A:CYS206 4.3 5.8 0.7 HA A:PRO138 4.3 8.4 0.6 C4 A:BE7303 4.3 8.5 0.7 HB A:VAL135 4.4 11.0 1.0 HD13 A:LEU204 4.4 12.1 1.0 CA A:GLN137 4.4 6.8 1.0 HB2 A:LEU204 4.5 8.0 1.0 C A:LEU204 4.6 5.4 1.0 CA A:GLU205 4.6 5.3 1.0 O A:ALA134 4.6 7.3 1.0 HD22 A:LEU204 4.7 12.8 1.0 N A:PRO138 4.7 6.3 0.6 O A:GLN136 4.7 8.7 0.6 N A:PRO138 4.7 6.7 0.4 O A:HOH615 4.8 33.0 1.0 H A:GLN136 4.8 9.5 0.6 H A:GLN136 4.8 9.8 0.5 CB A:VAL135 4.8 9.2 1.0 HA A:GLN137 4.9 8.2 1.0 O A:GLN136 4.9 8.2 0.5 C A:CYS206 4.9 5.1 0.7 CA A:LEU204 4.9 5.8 1.0 CA A:PRO138 5.0 7.4 0.4 C A:CYS206 5.0 6.2 0.3 CA A:PRO138 5.0 7.0 0.6

Mercury binding site 2 out of 2 in the Human Carbonic Anhydrase II in Complex with 4-Nitrobenzenesulfonamide.


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 2 of Human Carbonic Anhydrase II in Complex with 4-Nitrobenzenesulfonamide. within 5.0Å range: probe atom residue distance (Å) B Occ A:Hg303 b:7.1 occ:0.73 HG A:BE7303 0.0 7.1 0.7 HG A:HG302 1.3 11.7 0.3 C5 A:BE7303 2.2 7.2 0.7 SG A:CYS206 2.3 6.0 0.7 O A:HOH546 3.0 16.3 1.0 HB3 A:CYS206 3.0 11.5 0.3 O A:GLN137 3.0 6.6 1.0 O A:GLU205 3.0 6.8 1.0 HA A:CYS206 3.1 5.8 0.7 C6 A:BE7303 3.1 8.4 0.7 C4 A:BE7303 3.1 8.5 0.7 HA A:CYS206 3.1 9.1 0.3 HA A:PRO138 3.2 8.9 0.4 HA A:PRO138 3.3 8.4 0.6 CB A:CYS206 3.3 5.4 0.7 SG A:CYS206 3.4 9.6 0.3 CB A:CYS206 3.4 9.6 0.3 C A:GLN137 3.4 6.4 1.0 C A:GLU205 3.4 5.5 1.0 HB3 A:CYS206 3.5 6.5 0.7 CA A:CYS206 3.5 7.6 0.3 CA A:CYS206 3.5 4.9 0.7 N A:CYS206 3.7 6.7 0.3 N A:CYS206 3.8 4.9 0.7 H A:GLN137 3.8 8.8 1.0 O A:HOH569 3.8 11.9 1.0 N A:GLN137 3.8 7.3 1.0 N A:PRO138 3.9 6.3 0.6 N A:PRO138 3.9 6.7 0.4 CA A:PRO138 4.0 7.4 0.4 CA A:PRO138 4.0 7.0 0.6 H A:GLU205 4.0 6.4 1.0 CA A:GLN137 4.1 6.8 1.0 C A:GLN136 4.2 7.7 0.6 HB2 A:CYS206 4.2 6.5 0.7 O A:VAL135 4.2 9.5 1.0 C A:GLN136 4.2 7.6 0.5 HB3 A:LEU204 4.2 8.0 1.0 H A:CYS206 4.3 8.1 0.3 N A:GLU205 4.3 5.3 1.0 HB2 A:CYS206 4.3 11.5 0.3 HA A:GLN136 4.4 10.2 0.5 C7 A:BE7303 4.4 8.6 0.7 CA A:GLU205 4.4 5.3 1.0 HA A:GLN136 4.4 9.9 0.6 C3 A:BE7303 4.4 8.7 0.7 HA A:GLN137 4.4 8.2 1.0 H A:CYS206 4.5 5.8 0.7 HB2 A:GLU205 4.5 7.2 1.0 O A:GLN136 4.6 8.7 0.6 C A:VAL135 4.6 8.1 1.0 HD3 A:PRO138 4.7 8.3 0.6 HA A:VAL135 4.7 9.5 1.0 CA A:GLN136 4.7 8.2 0.6 HB3 A:PRO138 4.7 10.4 0.4 O A:HOH615 4.7 33.0 1.0 CA A:GLN136 4.7 8.5 0.5 O A:GLN136 4.8 8.2 0.5 CD A:PRO138 4.8 6.9 0.6 C A:PRO138 4.8 6.5 0.6 HD3 A:PRO138 4.8 8.7 0.4 O A:HOH610 4.8 25.3 1.0 HG3 A:PRO138 4.8 9.1 0.6 C2 A:BE7303 4.9 8.2 0.7 N A:GLN136 4.9 7.9 0.6 N A:GLN136 4.9 8.1 0.5 C A:PRO138 4.9 6.7 0.4 CB A:GLU205 5.0 6.0 1.0 C A:CYS206 5.0 5.1 0.7 CB A:PRO138 5.0 8.7 0.4 CD A:PRO138 5.0 7.2 0.4 C A:CYS206 5.0 6.2 0.3

S.Glockner, K.Ngo, B.Wagner, A.Heine, G.Klebe. The Influence of Varying Fluorination Patterns on the Thermodynamics and Kinetics of Benzenesulfonamide Binding to Human Carbonic Anhydrase II. Biomolecules V. 10 2020.
ISSN: ESSN 2218-273X
PubMed: 32230853
DOI: 10.3390/BIOM10040509