Mercury in PDB 6uqf: Human HCN1 Channel in A Hyperpolarized Conformation

The binding sites of Mercury atom in the Human HCN1 Channel in A Hyperpolarized Conformation (pdb code 6uqf). This binding sites where shown within 5.0 Angstroms radius around Mercury atom.
In total 4 binding sites of Mercury where determined in the Human HCN1 Channel in A Hyperpolarized Conformation, PDB code: 6uqf:
Jump to Mercury binding site number: 1; 2; 3; 4;

Mercury binding site 1 out of 4 in the Human HCN1 Channel in A Hyperpolarized Conformation


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 1 of Human HCN1 Channel in A Hyperpolarized Conformation within 5.0Å range: probe atom residue distance (Å) B Occ A:Hg902 b:0.6 occ:1.00 SG A:CYS264 2.2 0.3 1.0 SG A:CYS186 2.2 0.8 1.0 CB A:CYS264 3.0 0.3 1.0 CB A:CYS186 3.7 0.8 1.0 NE A:ARG267 3.8 0.2 1.0 CA A:CYS264 4.0 0.3 1.0 CE A:MET153 4.2 0.1 1.0 CD A:ARG267 4.2 0.2 1.0 CB A:SER228 4.3 0.5 1.0 OG A:SER182 4.4 0.2 1.0 ND2 A:ASN156 4.4 0.5 1.0 CZ A:ARG267 4.6 0.2 1.0 SD A:MET153 4.6 0.1 1.0 O A:SER228 4.7 0.5 1.0 NH2 A:ARG267 4.8 0.2 1.0 OG A:SER228 4.8 0.5 1.0 N A:CYS264 4.9 0.3 1.0 C A:SER228 4.9 0.5 1.0 O A:SER182 4.9 0.2 1.0 CA A:CYS186 4.9 0.8 1.0

Mercury binding site 2 out of 4 in the Human HCN1 Channel in A Hyperpolarized Conformation


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 2 of Human HCN1 Channel in A Hyperpolarized Conformation within 5.0Å range: probe atom residue distance (Å) B Occ B:Hg902 b:0.2 occ:1.00 SG B:CYS264 2.2 0.4 1.0 SG B:CYS186 2.2 0.9 1.0 CB B:CYS264 3.0 0.4 1.0 CB B:CYS186 3.7 0.9 1.0 NE B:ARG267 3.8 0.6 1.0 CA B:CYS264 4.0 0.4 1.0 CE B:MET153 4.2 0.0 1.0 CD B:ARG267 4.2 0.6 1.0 CB B:SER228 4.3 0.3 1.0 OG B:SER182 4.4 0.0 1.0 ND2 B:ASN156 4.4 0.6 1.0 CZ B:ARG267 4.6 0.6 1.0 SD B:MET153 4.6 0.0 1.0 O B:SER228 4.7 0.3 1.0 NH2 B:ARG267 4.8 0.6 1.0 OG B:SER228 4.8 0.3 1.0 N B:CYS264 4.9 0.4 1.0 C B:SER228 4.9 0.3 1.0 O B:SER182 4.9 0.0 1.0 CA B:CYS186 4.9 0.9 1.0

Mercury binding site 3 out of 4 in the Human HCN1 Channel in A Hyperpolarized Conformation


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 3 of Human HCN1 Channel in A Hyperpolarized Conformation within 5.0Å range: probe atom residue distance (Å) B Occ C:Hg902 b:0.1 occ:1.00 SG C:CYS264 2.2 0.4 1.0 SG C:CYS186 2.2 0.3 1.0 CB C:CYS264 3.0 0.4 1.0 CB C:CYS186 3.7 0.3 1.0 NE C:ARG267 3.8 0.4 1.0 CA C:CYS264 4.0 0.4 1.0 CE C:MET153 4.2 0.6 1.0 CD C:ARG267 4.2 0.4 1.0 CB C:SER228 4.3 0.8 1.0 OG C:SER182 4.4 0.8 1.0 ND2 C:ASN156 4.4 0.0 1.0 CZ C:ARG267 4.6 0.4 1.0 SD C:MET153 4.6 0.6 1.0 O C:SER228 4.7 0.8 1.0 NH2 C:ARG267 4.8 0.4 1.0 OG C:SER228 4.8 0.8 1.0 N C:CYS264 4.9 0.4 1.0 C C:SER228 4.9 0.8 1.0 O C:SER182 4.9 0.8 1.0 CA C:CYS186 4.9 0.3 1.0

Mercury binding site 4 out of 4 in the Human HCN1 Channel in A Hyperpolarized Conformation


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 4 of Human HCN1 Channel in A Hyperpolarized Conformation within 5.0Å range: probe atom residue distance (Å) B Occ D:Hg902 b:0.4 occ:1.00 SG D:CYS264 2.2 0.0 1.0 SG D:CYS186 2.2 0.2 1.0 CB D:CYS264 3.0 0.0 1.0 CB D:CYS186 3.7 0.2 1.0 NE D:ARG267 3.8 0.6 1.0 CA D:CYS264 4.0 0.0 1.0 CE D:MET153 4.2 0.5 1.0 CD D:ARG267 4.2 0.6 1.0 CB D:SER228 4.3 0.5 1.0 OG D:SER182 4.4 0.5 1.0 ND2 D:ASN156 4.4 0.8 1.0 CZ D:ARG267 4.6 0.6 1.0 SD D:MET153 4.6 0.5 1.0 O D:SER228 4.7 0.5 1.0 NH2 D:ARG267 4.8 0.6 1.0 OG D:SER228 4.8 0.5 1.0 N D:CYS264 4.9 0.0 1.0 C D:SER228 4.9 0.5 1.0 O D:SER182 4.9 0.5 1.0 CA D:CYS186 4.9 0.2 1.0

C.H.Lee, R.Mackinnon. Voltage Sensor Movements During Hyperpolarization in the Hcn Channel. Cell V. 179 1582 2019.
ISSN: ISSN 1097-4172
PubMed: 31787376
DOI: 10.1016/J.CELL.2019.11.006