Mercury in PDB 7wru: Crystal Structure of the Apo Chicken Glutamyl-Trna Synthetase 1 (EARS1)

All present enzymatic activity of Crystal Structure of the Apo Chicken Glutamyl-Trna Synthetase 1 (EARS1):
6.1.1.15; 6.1.1.17;

The structure of Crystal Structure of the Apo Chicken Glutamyl-Trna Synthetase 1 (EARS1), PDB code: 7wru was solved by S.Chung, Y.Cho, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	45.36 / 2.50
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	89.044, 41.762, 92.186, 90, 100.2, 90
R / Rfree (%)	22.4 / 27

The binding sites of Mercury atom in the Crystal Structure of the Apo Chicken Glutamyl-Trna Synthetase 1 (EARS1) (pdb code 7wru). This binding sites where shown within 5.0 Angstroms radius around Mercury atom.
In total 2 binding sites of Mercury where determined in the Crystal Structure of the Apo Chicken Glutamyl-Trna Synthetase 1 (EARS1), PDB code: 7wru:
Jump to Mercury binding site number: 1; 2;

Mercury binding site 1 out of 2 in the Crystal Structure of the Apo Chicken Glutamyl-Trna Synthetase 1 (EARS1)


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 1 of Crystal Structure of the Apo Chicken Glutamyl-Trna Synthetase 1 (EARS1) within 5.0Å range: probe atom residue distance (Å) B Occ A:Hg2001 b:177.0 occ:1.00 SG A:CYS337 2.2 25.4 1.0 CB A:CYS337 2.5 39.0 1.0 SD A:MET299 3.4 43.4 1.0 CE A:MET299 3.4 37.4 1.0 OG1 A:THR355 3.7 32.5 1.0 CA A:CYS337 3.9 28.4 1.0 NH2 A:ARG358 4.4 48.5 1.0 N A:CYS337 4.8 28.3 1.0 CB A:THR355 4.9 25.2 1.0 CG2 A:THR355 4.9 33.5 1.0 C A:CYS337 5.0 28.1 1.0

Mercury binding site 2 out of 2 in the Crystal Structure of the Apo Chicken Glutamyl-Trna Synthetase 1 (EARS1)


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 2 of Crystal Structure of the Apo Chicken Glutamyl-Trna Synthetase 1 (EARS1) within 5.0Å range: probe atom residue distance (Å) B Occ A:Hg2002 b:147.3 occ:1.00 SG A:CYS350 3.2 81.3 1.0 CB A:CYS350 3.5 40.2 1.0 NE A:ARG402 3.6 45.9 1.0 CA A:CYS350 3.7 31.6 1.0 CD A:ARG402 3.7 42.4 1.0 CZ A:ARG402 3.8 48.7 1.0 NH2 A:ARG402 4.1 51.2 1.0 N A:CYS350 4.1 26.4 1.0 NH1 A:ARG402 4.4 54.4 1.0 C A:GLY349 4.8 33.2 1.0 CB A:ASP401 4.9 43.4 1.0

S.Chung, M.S.Kang, D.S.Alimbetov, G.I.Mun, N.O.Yunn, Y.Kim, B.G.Kim, M.Wie, E.A.Lee, J.S.Ra, J.M.Oh, D.Lee, K.Lee, J.Kim, S.H.Han, K.T.Kim, W.K.Chung, K.H.Nam, J.Park, B.Lee, S.Kim, W.Zhao, S.H.Ryu, Y.S.Lee, K.Myung, Y.Cho. Regulation of BRCA1 Stability Through the Tandem Ubx Domains of Isoleucyl-Trna Synthetase 1. Nat Commun V. 13 6732 2022.
ISSN: ESSN 2041-1723
PubMed: 36347866
DOI: 10.1038/S41467-022-34612-Y