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Atomistry » Mercury » PDB 7tfx-9ca2 » 8eyl » |
Mercury in PDB 8eyl: Human Carbonic Anhydrase II with Tert-Butyl (2-(2-((2-(2,6- Dioxopiperidin-3-Yl)-1,3-Dioxoisoindolin-4-Yl)Amino)Ethoxy)Ethyl) CarbamateEnzymatic activity of Human Carbonic Anhydrase II with Tert-Butyl (2-(2-((2-(2,6- Dioxopiperidin-3-Yl)-1,3-Dioxoisoindolin-4-Yl)Amino)Ethoxy)Ethyl) Carbamate
All present enzymatic activity of Human Carbonic Anhydrase II with Tert-Butyl (2-(2-((2-(2,6- Dioxopiperidin-3-Yl)-1,3-Dioxoisoindolin-4-Yl)Amino)Ethoxy)Ethyl) Carbamate:
4.2.1.1; Protein crystallography data
The structure of Human Carbonic Anhydrase II with Tert-Butyl (2-(2-((2-(2,6- Dioxopiperidin-3-Yl)-1,3-Dioxoisoindolin-4-Yl)Amino)Ethoxy)Ethyl) Carbamate, PDB code: 8eyl
was solved by
A.J.Kohlbrand,
C.B.O'herin,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 8eyl:
The structure of Human Carbonic Anhydrase II with Tert-Butyl (2-(2-((2-(2,6- Dioxopiperidin-3-Yl)-1,3-Dioxoisoindolin-4-Yl)Amino)Ethoxy)Ethyl) Carbamate also contains other interesting chemical elements:
Mercury Binding Sites:
The binding sites of Mercury atom in the Human Carbonic Anhydrase II with Tert-Butyl (2-(2-((2-(2,6- Dioxopiperidin-3-Yl)-1,3-Dioxoisoindolin-4-Yl)Amino)Ethoxy)Ethyl) Carbamate
(pdb code 8eyl). This binding sites where shown within
5.0 Angstroms radius around Mercury atom.
In total only one binding site of Mercury was determined in the Human Carbonic Anhydrase II with Tert-Butyl (2-(2-((2-(2,6- Dioxopiperidin-3-Yl)-1,3-Dioxoisoindolin-4-Yl)Amino)Ethoxy)Ethyl) Carbamate, PDB code: 8eyl: Mercury binding site 1 out of 1 in 8eylGo back to Mercury Binding Sites List in 8eyl
Mercury binding site 1 out
of 1 in the Human Carbonic Anhydrase II with Tert-Butyl (2-(2-((2-(2,6- Dioxopiperidin-3-Yl)-1,3-Dioxoisoindolin-4-Yl)Amino)Ethoxy)Ethyl) Carbamate
Mono view Stereo pair view
Reference:
C.B.O'herin,
Y.W.Moriuchi,
T.A.Bemis,
A.J.Kohlbrand,
M.D.Burkart,
S.M.Cohen.
Development of Human Carbonic Anhydrase II Heterobifunctional Degraders. J.Med.Chem. 2023.
Page generated: Wed Apr 5 09:12:01 2023
ISSN: ISSN 0022-2623 PubMed: 36735827 DOI: 10.1021/ACS.JMEDCHEM.2C01843 |
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