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Mercury in PDB 1k4t: Human Dna Topoisomerase I (70 kDa) in Complex with the Poison Topotecan and Covalent Complex with A 22 Base Pair Dna Duplex

Enzymatic activity of Human Dna Topoisomerase I (70 kDa) in Complex with the Poison Topotecan and Covalent Complex with A 22 Base Pair Dna Duplex

All present enzymatic activity of Human Dna Topoisomerase I (70 kDa) in Complex with the Poison Topotecan and Covalent Complex with A 22 Base Pair Dna Duplex:
5.99.1.2;

Protein crystallography data

The structure of Human Dna Topoisomerase I (70 kDa) in Complex with the Poison Topotecan and Covalent Complex with A 22 Base Pair Dna Duplex, PDB code: 1k4t was solved by B.L.Staker, K.Hjerrild, M.D.Feese, C.A.Behnke, A.B.Burgin Jr., L.J.Stewart, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 19.89 / 2.10
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 57.093, 116.260, 75.217, 90.00, 94.16, 90.00
R / Rfree (%) n/a / n/a

Mercury Binding Sites:

The binding sites of Mercury atom in the Human Dna Topoisomerase I (70 kDa) in Complex with the Poison Topotecan and Covalent Complex with A 22 Base Pair Dna Duplex (pdb code 1k4t). This binding sites where shown within 5.0 Angstroms radius around Mercury atom.
In total only one binding site of Mercury was determined in the Human Dna Topoisomerase I (70 kDa) in Complex with the Poison Topotecan and Covalent Complex with A 22 Base Pair Dna Duplex, PDB code: 1k4t:

Mercury binding site 1 out of 1 in 1k4t

Go back to Mercury Binding Sites List in 1k4t
Mercury binding site 1 out of 1 in the Human Dna Topoisomerase I (70 kDa) in Complex with the Poison Topotecan and Covalent Complex with A 22 Base Pair Dna Duplex


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 1 of Human Dna Topoisomerase I (70 kDa) in Complex with the Poison Topotecan and Covalent Complex with A 22 Base Pair Dna Duplex within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Hg900

b:75.2
occ:0.36
 SG A:CYS630 2.8 44.3 1.0
CD2 A:LEU629 3.3 50.0 1.0
O A:ARG590 3.4 19.7 1.0
CB A:ALA486 3.7 42.3 1.0
CB A:ALA594 3.8 19.6 1.0
N A:ALA594 3.9 21.1 1.0
CA A:ALA594 4.0 18.8 1.0
CB A:CYS630 4.1 38.1 1.0
CA A:CYS630 4.2 38.7 1.0
CA A:ARG590 4.2 20.4 1.0
C A:ARG590 4.2 20.3 1.0
N A:CYS630 4.2 37.2 1.0
CG A:LEU629 4.5 49.4 1.0
CB A:ASN593 4.5 29.7 1.0
C A:ASN593 4.5 24.6 1.0
CB A:ARG590 4.5 25.1 1.0
C A:LEU629 4.6 39.4 1.0
CB A:LEU629 4.7 43.1 1.0
O A:VAL626 4.8 25.1 1.0
CG A:ARG590 4.9 28.3 1.0
O A:LEU629 4.9 39.2 1.0
CD1 A:LEU629 5.0 51.4 1.0

Reference:

B.L.Staker, K.Hjerrild, M.D.Feese, C.A.Behnke, A.B.Burgin Jr., L.J.Stewart. The Mechanism of Topoisomerase I Poisoning By A Camptothecin Analog Proc.Natl.Acad.Sci.Usa V. 99 15387 2002.
ISSN: ISSN 0027-8424
PubMed: 12426403
DOI: 10.1073/PNAS.242259599
Page generated: Fri Aug 8 09:11:28 2025

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