Mercury in PDB 7ca2: Engineering the Hydrophobic Pocket of Carbonic Anhydrase II

All present enzymatic activity of Engineering the Hydrophobic Pocket of Carbonic Anhydrase II:
4.2.1.1;

The structure of Engineering the Hydrophobic Pocket of Carbonic Anhydrase II, PDB code: 7ca2 was solved by S.K.Nair, D.W.Christianson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	N/A / 2.40
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	42.700, 41.700, 73.000, 90.00, 104.60, 90.00
R / Rfree (%)	n/a / n/a

The structure of Engineering the Hydrophobic Pocket of Carbonic Anhydrase II also contains other interesting chemical elements:

Zinc

(Zn)

1 atom

The binding sites of Mercury atom in the Engineering the Hydrophobic Pocket of Carbonic Anhydrase II (pdb code 7ca2). This binding sites where shown within 5.0 Angstroms radius around Mercury atom.
In total only one binding site of Mercury was determined in the Engineering the Hydrophobic Pocket of Carbonic Anhydrase II, PDB code: 7ca2:

Mercury binding site 1 out of 1 in the Engineering the Hydrophobic Pocket of Carbonic Anhydrase II


Mono view


Stereo pair view

A full contact list of Mercury with other atoms in the Hg binding site number 1 of Engineering the Hydrophobic Pocket of Carbonic Anhydrase II within 5.0Å range: probe atom residue distance (Å) B Occ A:Hg263 b:16.3 occ:1.00 SG A:CYS206 2.1 6.5 1.0 O A:GLN137 2.8 11.1 1.0 C A:GLN137 3.3 11.4 1.0 CB A:CYS206 3.3 7.5 1.0 CA A:CYS206 3.5 8.1 1.0 N A:GLN137 3.6 11.8 1.0 O A:GLU205 3.7 8.2 1.0 O A:HOH297 3.7 12.9 1.0 N A:CYS206 3.8 8.2 1.0 C A:GLU205 3.8 8.5 1.0 C A:GLN136 3.8 11.9 1.0 O A:VAL135 3.8 12.0 1.0 N A:PRO138 3.9 11.2 1.0 CA A:GLN137 3.9 11.6 1.0 C A:VAL135 4.0 11.9 1.0 N A:GLN136 4.2 12.0 1.0 CA A:PRO138 4.2 11.1 1.0 CA A:GLN136 4.2 12.0 1.0 O A:GLN136 4.3 11.9 1.0 O A:HOH312 4.3 8.8 1.0 N A:GLU205 4.6 9.4 1.0 CA A:VAL135 4.7 11.8 1.0 O A:ALA134 4.8 12.0 1.0 CA A:GLU205 4.8 9.0 1.0 C A:CYS206 4.9 8.4 1.0 CD A:PRO138 5.0 11.2 1.0

R.S.Alexander, S.K.Nair, D.W.Christianson. Engineering the Hydrophobic Pocket of Carbonic Anhydrase II. Biochemistry V. 30 11064 1991.
ISSN: ISSN 0006-2960
PubMed: 1932029
DOI: 10.1021/BI00110A008